ZNF878
Zinc finger protein 878
Also known as: ZN878_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- C9JN71
- Gene
- ZNF878
- Ensembl
- ENSG00000257446
- Chromosome
- 19
- Canonical length
- 531 aa
- Protein class
- Predicted intracellular proteins, Transcription factors
- Subcellular location
- Nucleoplasm,Nucleoli
OverviewNCBI Gene
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
531 residues, UniProt reviewed canonical sequence.
>C9JN71|ZNF878
1 MDSVAFEDVA VNFTQEEWAL LDPSQKNLYR EVMQETLRNL TSIGKKWNNQ YIEDEHQNPR
61 RNLRRLIGER LSESKESHQH GEVLTQVPDD TLKKKTPGVQ SYESSVCGEI GIGLSSLNRH
121 LRAFSYSSSL AIHGRTHTGE KPYECKECGK AFRFPSSVRR HERIHSAKKP YECKQCGKAF
181 SFPSSVRRHE RIHSAKKPYE CKQCGKALSY LVSFQTHMRM HTGERPHKCN ICGKAFFSPS
241 SLKRHEKSHT GEKRYKCKQC DKAFNCPSSF QYHERTHSGE KPYECTQCRK AFRSVKYLRV
301 HERKHTGEKP YECKLCGKGF ISSTSFRYHE KTHTGEKPYE CKKCVKAFSF VKDLRIHERT
361 HTGEKPFECK QCGKTFTSSN SFHYHERTHT GEKPYECKQC GKAFRSASVL QKHIRTHTGE
421 KPYGCKQCGK VFRVASQLKM HERTHTGEKP YECKQCGKAF ISSNSIRYHK RTHTGEKPYK
481 CKQCGKAFIS SNSFLYHERI HTGEKPYECK QCGKAFRSAS ILQKHVRTHA GLocalizationUniProt · AlphaFold · HPA
Whether an antibody against ZNF878 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.41
- Highest tissue expression
- 1.2 nTPM
Expression across tissuesHPA
Tissue
- bone marrow: 1.2 nTPM
- testis: 0.9 nTPM
- kidney: 0.7 nTPM
- placenta: 0.7 nTPM
- ovary: 0.5 nTPM
- pancreas: 0.5 nTPM
Single-cell type
- breast hormone-responsive cells: 0.2 nCPM
- breast lactating cells: 0.2 nCPM
- epididymal basal cells: 0.2 nCPM
- macrophages: 0.2 nCPM
- smooth muscle cells: 0.2 nCPM
- differentiating spermatogonia: 0.1 nCPM
Immune cell
- NK-cell: 0.2 nTPM
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
Brain region
- cerebellum: 1.7 nTPM
- cerebral cortex: 1.2 nTPM
- thalamus: 1 nTPM
- midbrain: 0.9 nTPM
- pons: 0.9 nTPM
- spinal cord: 0.8 nTPM
DiseaseUniProt · ClinVar · IEDB · PubMed
Four sources answering four different questions about ZNF878.
Disease | ImmuneIEDB
Conditions an epitope on ZNF878 was assayed in.
- melanoma T cell
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.4
- gnomAD pLI
- 0.08
- gnomAD missense Z
- 0.82
- DepMap mean gene effect
- 0.07
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
- DNA-binding transcription factor activity, RNA polymerase II-specific
- RNA polymerase II transcription regulatory region sequence-specific DNA binding
- zinc ion binding
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads ZNF878 as an antibody target. Whether an autoantibody or antibody against ZNF878 could matter depends on whether native ZNF878 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
ZNF878 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label ZNF878 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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