Seroatlas · Human Serome Atlas

ZNF875

Zinc finger protein 875

Also known as: HKR1, ZN875_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P10072
Gene: ZNF875
Ensembl: ENSG00000181666
Chromosome: 19
Canonical length: 659 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Mitochondria

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

659 residues, UniProt reviewed canonical sequence.

>P10072|ZNF875
     1  MRVNHTVSTM LPTCMVHRQT MSCSGAGGIT AFVAFRDVAV YFTQEEWRLL SPAQRTLHRE
    61  VMLETYNHLV SLEIPSSKPK LIAQLERGEA PWREERKCPL DLCPESKPEI QLSPSCPLIF
   121  SSQQALSQHV WLSHLSQLFS SLWAGNPLHL GKHYPEDQKQ QQDPFCFSGK AEWIQEGEDS
   181  RLLFGRVSKN GTSKALSSPP EEQQPAQSKE DNTVVDIGSS PERRADLEET DKVLHGLEVS
   241  GFGEIKYEEF GPGFIKESNL LSLQKTQTGE TPYMYTEWGD SFGSMSVLIK NPRTHSGGKP
   301  YVCRECGRGF TWKSNLITHQ RTHSGEKPYV CKDCGRGFTW KSNLFTHQRT HSGLKPYVCK
   361  ECGQSFSLKS NLITHQRAHT GEKPYVCREC GRGFRQHSHL VRHKRTHSGE KPYICRECEQ
   421  GFSQKSHLIR HLRTHTGEKP YVCTECGRHF SWKSNLKTHQ RTHSGVKPYV CLECGQCFSL
   481  KSNLNKHQRS HTGEKPFVCT ECGRGFTRKS TLSTHQRTHS GEKPFVCAEC GRGFNDKSTL
   541  ISHQRTHSGE KPFMCRECGR RFRQKPNLFR HKRAHSGAFV CRECGQGFCA KLTLIKHQRA
   601  HAGGKPHVCR ECGQGFSRQS HLIRHQRTHS GEKPYICRKC GRGFSRKSNL IRHQRTHSG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF875 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.5
Highest tissue expression: 130 nTPM

Expression across tissuesHPA

Tissue

retina: 130 nTPM
choroid plexus: 52 nTPM
prostate: 38 nTPM
thyroid gland: 36 nTPM
cerebellum: 36 nTPM
adrenal gland: 36 nTPM

Single-cell type

cardiomyocytes: 322 nCPM
rod photoreceptor cells: 241 nCPM
cone photoreceptor cells: 217 nCPM
choroid plexus epithelial cells: 157 nCPM
retinal bipolar cells: 108 nCPM
sertoli cells: 99 nCPM

Immune cell

MAIT T-cell: 14 nTPM
naive CD4 T-cell: 14 nTPM
T-reg: 13 nTPM
basophil: 13 nTPM
naive B-cell: 12 nTPM
naive CD8 T-cell: 12 nTPM

Brain region

choroid plexus: 110 nTPM
cerebellum: 86 nTPM
hypothalamus: 75 nTPM
cerebral cortex: 73 nTPM
white matter: 72 nTPM
basal ganglia: 71 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.44
gnomAD pLI: 0
DepMap mean gene effect: 0.13
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of transcription by RNA polymerase II

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF875 as an antibody target. Whether an autoantibody or antibody against ZNF875 could matter depends on whether native ZNF875 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF875 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF875 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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