Seroatlas · Human Serome Atlas

ZNF860

Zinc finger protein 860

Also known as: ZN860_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A6NHJ4
Gene: ZNF860
Ensembl: ENSG00000197385
Chromosome: 3
Canonical length: 632 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Nucleoli,Nucleoli rim

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

632 residues, UniProt reviewed canonical sequence.

>A6NHJ4|ZNF860
     1  MLREEAAQKR KEKEPGMALP QGHLTFRDVA IEFSLEEWKC LDPTQRALYR AMMLENYRNL
    61  HSVDISSKCM MKKFSSTAQG NTEVDTGTLE RHESHHIGDF CFQKIGKDIH DFEFQWQEDK
   121  RNSHEATMTQ IKKLTGSTDR YDRRHPGNKP IKDQLGLSFH SHLPELHIFQ TKGKVGNQVE
   181  KSINDASSVL TSQRISSRPK IHISNNYENN FFHSSLLTLK QEVHIREKSF QCNESGKAFN
   241  CSSLLRKHQI IYLGGKQYKC DVCGKVFNQK RYLACHHRCH TGEKPYKCNE CGKVFNQQSN
   301  LASHHRLHTG EKPYKCEECD KVFSRKSNLE RHRRIHTGEK PYKCKVCEKA FRRDSHLTQH
   361  TRIHTGEKPY KCNECGKAFS GQSTLIHHQA IHGIGKLYKC NDCHKVFSNA TTIANHWRIH
   421  NEERSYKCNK CGKFFRRRSY LVVHWRTHTG EKPYKCNECG KTFHHNSALV IHKAIHTGEK
   481  PYKCNECGKT FRHNSALVIH KAIHTGEKPY KCNECGKVFN QQATLARHHR LHTGEKPYKC
   541  EECDTVFSRK SHHETHKRIH TGEKPYKCDD FDEAFSQASS YAKQRRIHMG EKHHKCDDCG
   601  KAFTSHSHRI RHQRIHTGQK SYKCHKRGKV FS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF860 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.46
Highest tissue expression: 3.9 nTPM

Expression across tissuesHPA

Tissue

tonsil: 3.9 nTPM
lymph node: 2.9 nTPM
prostate: 2.6 nTPM
epididymis: 2.2 nTPM
esophagus: 1.5 nTPM
spleen: 1.5 nTPM

Single-cell type

corticotrophs: 32 nCPM
b-cells: 31 nCPM
pituitary stem cells: 28 nCPM
esophageal apical cells: 23 nCPM
müller glia: 18 nCPM
breast lactating cells: 14 nCPM

Immune cell

memory B-cell: 7 nTPM
naive B-cell: 5.3 nTPM
basophil: 0.1 nTPM
total PBMC: 0.1 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM

Brain region

choroid plexus: 1.9 nTPM
midbrain: 1.9 nTPM
cerebral cortex: 1.4 nTPM
pons: 1.4 nTPM
hypothalamus: 1.3 nTPM
basal ganglia: 1.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD missense Z: 0.87
DepMap mean gene effect: 0
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of transcription by RNA polymerase II

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF860 as an antibody target. Whether an autoantibody or antibody against ZNF860 could matter depends on whether native ZNF860 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF860 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF860 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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