Seroatlas · Human Serome Atlas

ZNF853

Zinc finger protein 853

Also known as: DKFZp434J1015, ZN853_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P0CG23
Gene
ZNF853
Ensembl
ENSG00000236609
Chromosome
7
Canonical length
659 aa
Protein class
Predicted intracellular proteins, Transcription factors
Subcellular location
Nucleoli

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

659 residues, UniProt reviewed canonical sequence.

>P0CG23|ZNF853
     1  MLHQPTPGNR GLTARMEVGP ATETFVLELQ CLEDGGPGPD TLSGGSGGSE SQEEEEPQER
    61  NSSPQRPAVS APVGASEIAE ETRPGQRELQ LQQLEQQPEP QQQPQHEQLQ QPQPHLELQQ
   121  QPQQDGQQQL SQLQQEKHQS VHHQELKPEL QLMHQQQQLQ PQQVQEQQRL QQQQEQLQTQ
   181  QAQEQQVLQQ QEQLQQQVQE QQLLQQQQEQ LQQQQLLQQQ EQLQQQQFQQ QQEQLQQQQQ
   241  LLLLQQQGQL QQQLLQQQQA QLQQQLLEQQ QAQLQQQLLL QQQEQLQQQQ QQQLLQQQQE
   301  QLQQQQLQPP PLEPEEEEEV ELELMPVDLG SEQELEQQRQ ELERQQELER QQEQRQLQLK
   361  LQEELQQLEQ QLEQQQQQLE QQEVQLELTP VELGAQQQEV QLELTPVQPE LQLELVPAAG
   421  GGGAAVPGAP AAVVVAPPGY VVVQELMVLP AVAAPAVVAI PGPAGSAALT PARQRRRRRA
   481  RDRPTICGEC GKGFSRSTDL VRHQATHTGE RPHRCGECGK GFSQHSNLVT HQRIHTGEKP
   541  YACSYCAKRF SESSALVQHQ RTHTGERPYA CGDCGKRFSV SSNLLRHRRT HSGERPYVCE
   601  DCGERFRHKV QIRRHERQLH GAGRSRGLGL LRASRPAALG GPARAEQAAT ATAPADKAL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF853 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.57
Highest tissue expression
25 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 25 nTPM
  • amygdala: 24 nTPM
  • hippocampal formation: 24 nTPM
  • cerebral cortex: 22 nTPM
  • hypothalamus: 22 nTPM
  • midbrain: 22 nTPM

Single-cell type

  • müller glia: 13 nCPM
  • fallopian tube ciliated cells: 12 nCPM
  • respiratory ciliated cells: 11 nCPM
  • respiratory ionocytes: 10 nCPM
  • schwann cells: 10 nCPM
  • retinal bipolar cells: 9.9 nCPM

Immune cell

  • eosinophil: 0.8 nTPM
  • MAIT T-cell: 0.3 nTPM
  • memory CD8 T-cell: 0.3 nTPM
  • naive CD8 T-cell: 0.3 nTPM
  • gdT-cell: 0.2 nTPM
  • NK-cell: 0.2 nTPM

Brain region

  • midbrain: 44 nTPM
  • medulla oblongata: 43 nTPM
  • spinal cord: 38 nTPM
  • pons: 37 nTPM
  • thalamus: 37 nTPM
  • amygdala: 36 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.52
gnomAD pLI
0
gnomAD missense Z
1.93
DepMap mean gene effect
0.09
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF853 as an antibody target. Whether an autoantibody or antibody against ZNF853 could matter depends on whether native ZNF853 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF853 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF853 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ZNF853. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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