Seroatlas · Human Serome Atlas

ZNF852

Zinc finger protein 852

Also known as: ZN852_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6ZMS4
Gene: ZNF852
Ensembl: ENSG00000178917
Chromosome: 3
Canonical length: 543 aa
Protein class: Predicted intracellular proteins
Subcellular location: Cytosol

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

543 residues, UniProt reviewed canonical sequence.

>Q6ZMS4|ZNF852
     1  MVRPQDTVAY EDLSEDYTQK KWKGLALSQR ALHWNMMLEN DRSMASLGRN MMESSELTPK
    61  QEIFKGSESS NSTSGGLFGV VPGGTETGDV CEDTFKELEG QPSNEEGSRL ESDFLEIIDE
   121  DKKKSTKDRY EEYKEVEEHP PLSSSPVEHE GVLKGQKSYR CDECGKAFYW SSHLIGHRRI
   181  HTGEKPYECN ECGKTFRQTS QLIVHLRTHT GEKPYECSEC GKAYRHSSHL IQHQRLHNGE
   241  KPYKCNECAK AFNQSSKLFD HQRTHTGEKP YECKECGAAF SRSKNLVRHQ FLHTGKKPYK
   301  CNECGRAFCS NRNLIDHQRT HTGEKPYKCN ECGKAFSRSK CLIRHQSLHT GEKPYKCSEC
   361  GKAFNQISQL VEHERIHTGE KPFKCSECGK AFGLSKCLIR HQRLHTSEKP YKCNECGKSF
   421  NQNSYLIIHQ RIHTGEKPYE CNECGKVFSY NSSLMVHQRT HTGEKPYKCN SCGKAFSDSS
   481  QLTVHQRVHT GEKNLMNVLS VGKPLVSVPL LITTSELMLE RSPQVWLGHL LKAWFSETDS
   541  KDL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF852 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.47
Highest tissue expression: 3.4 nTPM

Expression across tissuesHPA

Tissue

salivary gland: 3.4 nTPM
tonsil: 3 nTPM
pancreas: 2.9 nTPM
rectum: 2.9 nTPM
stomach: 2.9 nTPM
parathyroid gland: 2.7 nTPM

Single-cell type

oligodendrocyte progenitor cells: 15 nCPM
bergmann glia: 15 nCPM
choroid plexus epithelial cells: 14 nCPM
oligodendrocytes: 13 nCPM
brain excitatory neurons: 13 nCPM
brain inhibitory neurons: 12 nCPM

Immune cell

plasmacytoid DC: 1.4 nTPM
memory B-cell: 1.1 nTPM
naive B-cell: 0.8 nTPM
eosinophil: 0.7 nTPM
naive CD8 T-cell: 0.7 nTPM
intermediate monocyte: 0.5 nTPM

Brain region

choroid plexus: 11 nTPM
cerebellum: 11 nTPM
hypothalamus: 5.8 nTPM
pons: 5.5 nTPM
cerebral cortex: 5.3 nTPM
medulla oblongata: 5.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.21
gnomAD pLI: 0
gnomAD missense Z: 0

OntologyGO

Biological processes

regulation of transcription by RNA polymerase II

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF852 as an antibody target. Whether an autoantibody or antibody against ZNF852 could matter depends on whether native ZNF852 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF852 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF852 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...