Seroatlas · Human Serome Atlas

ZNF850

Zinc finger protein 850

Also known as: ZN850_HUMAN, ZNF850P

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A8MQ14
Gene: ZNF850
Ensembl: ENSG00000267041
Chromosome: 19
Canonical length: 1090 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Predicted to enable DNA binding activity and zinc ion binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1090 residues, UniProt reviewed canonical sequence.

>A8MQ14|ZNF850
     1  MNMEGLVMFQ DLSIDFSQEE WECLDAAQKD LYRDVMMENY SSLVSLGLSI PKPDVISLLE
    61  QGKEPWMVSR DVLGGWCRDS EFRCKTKDSC LPKEIYEVTS SQWVRMEKCH SLVGSSVRDD
   121  WECKGQFQHQ DINQERYLEK AIMTYETTPT FCLQTSLTLH HRIHPGEKLY KSTECMAFKY
   181  GSELTQQQET HTGEKLYKCK ECGKAFHHFS YLVKHQRIHT GEKPCACKEY GKAFISGSHL
   241  IQHQKMYTDE RPHECQESVK AFRPSAHLIQ HWRIHTGDKP YECKECGKSF TSGSTLNQHQ
   301  QIHTGEKPYH CKQCGKSFTV GSTLIRHQQI HTGEKPYDCK ECGKSFASGS ALIRHQRIHT
   361  GEKPYDCKEC GKSFTFHSAL IRHQRIHTGE KPYDCKECGK SFTFRSGLIG HQAIHTGEKP
   421  YDCKECGKSF TAGSTLIQHQ RIHTGEKPYD CKECGKSFAS GSALLQHQRI HTGEKPYCCK
   481  ECGKSFTFRS TRNRHQRIHT GEKPYNCKEC GKSFASGSAL LQHQRIHTGE KPYHCKECGK
   541  SFTFRSGLIG HQAVHTGEKP YDCKECGKSF TSRSALIQHQ RIHTGEKPYH CKECGKSFTV
   601  GSTLLQHQQI HTGEKPYDCK ECGKAFRLRL RLTQHQQIHT GEKPYQCQEC GKAFVSVSGL
   661  TQHHRIHTGE KPYECPDCGK AFRQRTYLNQ HRRIHTGEKP YECKECGKSF TFCSGLIQHQ
   721  QNHTDEKPYD GKECGKSFTS HSTLIQHQQI HTGEKPYDCK ECGKSFTSHS TLIQHQQIHT
   781  GEKLYDCKEC GKSFTSHSTL IQHQPLHTGE KPYHCKECGK SFTLRSALIQ HRPVHTGEKR
   841  YSCKECGKSF TSRSTLIEHQ RIHTGEKPYH CKECGKSFAF RSAIIQHRRI HTGEKPYDCK
   901  ECGKAFRRRS KLTQHQRIHT GEKPYRCHEC GKAFVRFSGL TKHHSIHTGE KPYECKTCGK
   961  SFRQRTHLTL HQRIHTGDRP YECKECGKSF TCGSELIRHQ RTHTGEKPYD CKECGKAFRC
  1021  PSQLSQHKRI HTGEKTYQCP ECGKAFFYAS GLSRHQSVHT GEKPYECKTC GKAFKQLTQL
  1081  TRHQRIHDLT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF850 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.42
Highest tissue expression: 5.1 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 5.1 nTPM
placenta: 2.8 nTPM
testis: 2.4 nTPM
heart muscle: 1.5 nTPM
lymph node: 1.4 nTPM
ovary: 1.2 nTPM

Single-cell type

cardiomyocytes: 97 nCPM
epicardial cells: 68 nCPM
erythrocyte progenitors: 52 nCPM
megakaryocyte-erythroid progenitors: 41 nCPM
megakaryocyte progenitors: 32 nCPM
early primary spermatocytes: 29 nCPM

Immune cell

memory B-cell: 2.7 nTPM
total PBMC: 2 nTPM
naive CD8 T-cell: 1.9 nTPM
naive CD4 T-cell: 1.8 nTPM
basophil: 1.7 nTPM
MAIT T-cell: 1.7 nTPM

Brain region

cerebellum: 10 nTPM
hippocampal formation: 8.3 nTPM
white matter: 7.8 nTPM
cerebral cortex: 7.3 nTPM
medulla oblongata: 7.2 nTPM
midbrain: 7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.71
gnomAD pLI: 0.72
gnomAD missense Z: 3
DepMap mean gene effect: 0.11
DepMap dependency class: none

OntologyGO

Biological processes

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF850 as an antibody target. Whether an autoantibody or antibody against ZNF850 could matter depends on whether native ZNF850 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF850 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF850 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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