Seroatlas · Human Serome Atlas

ZNF845

Zinc finger protein 845

Also known as: ZN845_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96IR2
Gene: ZNF845
Ensembl: ENSG00000213799
Chromosome: 19
Canonical length: 970 aa
Protein class: Predicted intracellular proteins, Transcription factors

OverviewNCBI Gene

Predicted to enable DNA binding activity and zinc ion binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

970 residues, UniProt reviewed canonical sequence.

>Q96IR2|ZNF845
     1  MALSQGLLTF RDVAIEFSQE EWKCLDPAQR TLYRDVMLEN YRNLVSLDIS SKCMMKEFSS
    61  TAQGNTEVIH TGTLQRHERH HIGDFCFQEM EKDIHDFEFQ WKEDERNSHE APMTEIKQLT
   121  GSTNRHDQRH AGNKPIKDQL GSSFHSHLPE LHMFQTEGKI GNQVEKSINS ASLVSTSQRI
   181  SCRPKTHISK NYGNNFLNSS LLTQKQEVHM REKSFQCNES GKAFNYSSVL RKHQIIHLGA
   241  KQYKCDVCGK VFNQKRYLAC HRRCHTGKKP YKCNDCGKTF SQELTLTCHH RLHTGEKHYK
   301  CSECGKTFSR NSALVIHKAI HTGEKSYKCN ECGKTFSQTS YLVYHRRLHT GEKPYKCEEC
   361  DKAFSFKSNL ERHRKIHTGE KPYKCNECSR TFSRKSSLTR HRRLHTGEKP YKCNDCGKTF
   421  SQMSSLVYHR RLHTGEKPYK CEECDEAFSF KSNLERHRRI HTGEKPYKCN DCGKTFSQTS
   481  SLVYHRRLHT GEKPYKCEEC DEAFSFKSNL ERHRIIHTGE KLYKCNECGK TFSRKSSLTR
   541  HCRLHTGEKP YQCNECGKAF RGQSALIYHQ AIHGIGKLYK CNDCHQVFSN ATTIANHWRI
   601  HNEERSYKCN RCGKFFRHRS YLAVHWRTHS GEKPYKCEEC DEAFSFKSNL QRHRRIHTGE
   661  KPYRCNECGK TFSRKSYLTC HRRLHTGEKP YKCNECGKTF GRNSALIIHK AIHTGEKPYK
   721  CNECGKAFSQ KSSLTCHLRL HTGEKPYKCE ECDKVFSRKS SLEKHRRIHT GEKPYKCKVC
   781  DKAFGRDSHL AQHTRIHTGE KPYKCNECGK NFRHNSALVI HKAIHSGEKP YKCNECGKTF
   841  RHNSALEIHK AIHTGEKPYK CSECGKVFNR KANLSRHHRL HTGEKPYKCN KCGKVFNQQA
   901  HLACHHRIHT GEKPYKCNEC GKTFRHNSVL VIHKTIHTGE KPYKCNECGK VFNRKAKLAR
   961  HHRIHTGKKH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF845 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.44
Highest tissue expression: 4.7 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 4.7 nTPM
lymph node: 4 nTPM
thymus: 3.9 nTPM
breast: 3.8 nTPM
ovary: 3.7 nTPM
tonsil: 3.6 nTPM

Single-cell type

syncytiotrophoblasts: 19 nCPM
retinal horizontal cells: 14 nCPM
undifferentiated spermatogonia: 13 nCPM
nk-cells: 13 nCPM
b-cells: 11 nCPM
erythrocyte progenitors: 10 nCPM

Immune cell

T-reg: 3.8 nTPM
MAIT T-cell: 3.3 nTPM
memory B-cell: 3.3 nTPM
memory CD8 T-cell: 3.3 nTPM
naive CD4 T-cell: 3.3 nTPM
naive CD8 T-cell: 3.1 nTPM

Brain region

cerebellum: 5.5 nTPM
white matter: 5.1 nTPM
basal ganglia: 4.2 nTPM
choroid plexus: 4.2 nTPM
hypothalamus: 4.1 nTPM
medulla oblongata: 4.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.9
gnomAD pLI: 0
gnomAD missense Z: -0.12
DepMap mean gene effect: 0.05
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of transcription by RNA polymerase II

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZNF845 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

TRIM28

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF845 as an antibody target. Whether an autoantibody or antibody against ZNF845 could matter depends on whether native ZNF845 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF845 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF845 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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