Seroatlas · Human Serome Atlas

ZNF844

Zinc finger protein 844

Also known as: FLJ14959, ZN844_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q08AG5
Gene: ZNF844
Ensembl: ENSG00000223547
Chromosome: 19
Canonical length: 666 aa
Protein class: Cancer-related genes, Predicted intracellular proteins, Transcription factors

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

666 residues, UniProt reviewed canonical sequence.

>Q08AG5|ZNF844
     1  MDLVAFEDVA VNFTQEEWSL LDPSQKNLYR EVMQETLRNL ASIGEKWKDQ NIEDQYKNPR
    61  NNLRSLLGER VDENTEENHC GETSSQIPDD TLNKKTSPGV KSCESSVCGE VFVGHSSLNR
   121  HIRADTAHKP SEYQEYGQEP YKCQQRKKAF RCHPSFQMQE KAHTGEKLYD CKECGKTFIS
   181  HSSIQRHMIM HNGDGTYKCK FCGKACPCLS IYLIHERVHT GEKPYKCKQC GKAFSYSTSL
   241  QIHERTHTGE KPYECKECGK AFGSPNSLYE HRRTHTGEKP YECKQCGKAF RWFHSFQIHE
   301  RTHSEEKAYE CTKCGKAFKC PSYLCRHEVT HSGKKPCECK QCGKALSYLN FQRHMKMHTR
   361  MRPYKCKTVE KPLILPVRFE DMKELTLERN LMNASTVVKP SIVPVPFTIM KGLTLERNPM
   421  NVSSVVKPSF LPLPFDIMKG LTLERNRMSV SNVGKPSDLP HTFKCMEGLT LKRNPMNVSS
   481  VVKPSFFPLP FDIMKGLTLE RNPMSVSNVG KPSHLPHTFK CMKGLTLESN CMNLNNVKKP
   541  LDLSETFKFM KRHTLERNPI RNMEKHSTIS LPFKYMQQCT EDRMPMNVKS VTKHSYLPRS
   601  FEYMQEHTLE RNPMNVRNAE KRSIIFLLCV YTKGCTLERN HINVRIVGKH SVCLVPFVDI
   661  KGLTLE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF844 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.41
Highest tissue expression: 11 nTPM

Expression across tissuesHPA

Tissue

retina: 11 nTPM
thyroid gland: 7.1 nTPM
parathyroid gland: 6.7 nTPM
kidney: 6.4 nTPM
ovary: 6 nTPM
heart muscle: 4.9 nTPM

Single-cell type

distal convoluted tubule cells: 35 nCPM
loop of henle epithelial cells: 32 nCPM
proximal tubule cells: 32 nCPM
choroid plexus epithelial cells: 26 nCPM
renal connecting tubule cells: 25 nCPM
renal collecting duct intercalated cells: 24 nCPM

Immune cell

basophil: 3.1 nTPM
neutrophil: 1.8 nTPM
eosinophil: 1.2 nTPM
intermediate monocyte: 0.8 nTPM
NK-cell: 0.7 nTPM
memory B-cell: 0.6 nTPM

Brain region

cerebellum: 20 nTPM
white matter: 17 nTPM
choroid plexus: 13 nTPM
basal ganglia: 13 nTPM
medulla oblongata: 12 nTPM
thalamus: 12 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.79
gnomAD pLI: 0
gnomAD missense Z: -0.32
DepMap mean gene effect: 0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of transcription by RNA polymerase II

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF844 as an antibody target. Whether an autoantibody or antibody against ZNF844 could matter depends on whether native ZNF844 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF844 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF844 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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