Seroatlas · Human Serome Atlas

ZNF843

Zinc finger protein 843

Also known as: MGC46336, ZN843_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N446
Gene: ZNF843
Ensembl: ENSG00000176723
Chromosome: 16
Canonical length: 348 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nuclear speckles

OverviewNCBI Gene

Predicted to enable zinc ion binding activity. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

348 residues, UniProt reviewed canonical sequence.

>Q8N446|ZNF843
     1  MRSLPFALTV ESVSARAPTC CSTGRFTQGR QPCKCKACGR GFTQSASLLQ HWRVHSDWRE
    61  TLSLSPVRQD LLWPLQPHQA PASPLGRSHS SAGVRQGFSG QLCCWLTKEH TLAEALRLSP
   121  VPAGFWGPVE ADRPPANSHR RVCPFCCCSC GDSVNEKTSL SQRVLPHPGE KTCRGGSVES
   181  VSLAPSSVAP DSTSGLRPCG SPGSFLQHLP PSTLLPRPPF LYPGPPLSLQ PLVPSGLPAV
   241  PAVPLGGLEV AQVPPATQPA AQQEGAMGPR SCASAGRDSR EAVQAPGYPE PARKASQHRA
   301  AGPLGEARAR LQRQCRAPPP PSNPHWRGAL PVFPVWKASS RRSNLARH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF843 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.69
Highest tissue expression: 2.3 nTPM

Expression across tissuesHPA

Tissue

ovary: 2.3 nTPM
skeletal muscle: 2.1 nTPM
pancreas: 2 nTPM
cerebral cortex: 1.8 nTPM
amygdala: 1.7 nTPM
basal ganglia: 1.6 nTPM

Single-cell type

myonuclei: 11 nCPM
cardiomyocytes: 7.8 nCPM
oligodendrocyte progenitor cells: 6.1 nCPM
retinal amacrine cells: 5.5 nCPM
medullary thymic epithelial cells: 4.8 nCPM
lactotrophs: 4.6 nCPM

Immune cell

NK-cell: 1.7 nTPM
basophil: 0.8 nTPM
total PBMC: 0.7 nTPM
neutrophil: 0.6 nTPM
gdT-cell: 0.5 nTPM
memory CD8 T-cell: 0.5 nTPM

Brain region

cerebellum: 7.9 nTPM
hypothalamus: 6.9 nTPM
hippocampal formation: 6.2 nTPM
amygdala: 6.1 nTPM
midbrain: 6 nTPM
basal ganglia: 5.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD missense Z: 1.05
DepMap mean gene effect: 0.07
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF843 as an antibody target. Whether an autoantibody or antibody against ZNF843 could matter depends on whether native ZNF843 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF843 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF843 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...