Seroatlas · Human Serome Atlas

ZNF841

Zinc finger protein 841

Also known as: LOC284371, ZN841_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6ZN19
Gene: ZNF841
Ensembl: ENSG00000197608
Chromosome: 19
Canonical length: 808 aa
Protein class: Predicted intracellular proteins, Transcription factors

OverviewNCBI Gene

Predicted to enable DNA binding activity and zinc ion binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

808 residues, UniProt reviewed canonical sequence.

>Q6ZN19|ZNF841
     1  MLEGHESYDT ENFYFREIRK NLQEVDFQWK DGEINYKEGP MTHKNNLTGQ RVRHSQGDVE
    61  NKHMENQLIL RFQSGLGELQ KFQTAEKIYG CNQIERTVNN CFLASPLQRI FPGVQTNISR
   121  KYGNDFLQLS LPTQDEKTHI REKPYIGNEC GKAFRVSSSL INHQMIHTTE KPYRCNESGK
   181  AFHRGSLLTV HQIVHTRGKP YQCDVCGRIF RQNSDLVNHR RSHTGDKPYI CNECGKSFSK
   241  SSHLAVHQRI HTGEKPYKCN RCGKCFSQSS SLATHQTVHT GDKPYKCNEC GKTFKRNSSL
   301  TAHHIIHAGK KPYTCDVCGK VFYQNSQLVR HQIIHTGETP YKCNECGKVF FQRSRLAGHR
   361  RIHTGEKPYK CNECGKVFSQ HSHLAVHQRV HTGEKPYKCN ECGKAFNWGS LLTVHQRIHT
   421  GEKPYKCNVC GKVFNYGGYL SVHMRCHTGE KPLHCNKCGM VFTYYSCLAR HQRMHTGEKP
   481  YKCNVCGKVF IDSGNLSIHR RSHTGEKPFQ CNECGKVFSY YSCLARHRKI HTGEKPYKCN
   541  DCGKAYTQRS SLTKHLVIHT GENPYHCNEF GEAFIQSSKL ARYHRNPTGE KPHKCSECGR
   601  TFSHKTSLVY HQRRHTGEMP YKCIECGKVF NSTTTLARHR RIHTGEKPYK CNECGKVFRY
   661  RSGLARHWSI HTGEKPYKCN ECGKAFRVRS ILLNHQMMHT GEKPYKCNEC GKAFIERSNL
   721  VYHQRNHTGE KPYKCMECGK AFGRRSCLTK HQRIHSSEKP YKCNECGKSY ISRSGLTKHQ
   781  IKHAGENLTT KLNVERPLDV VLTSGIPK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF841 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.44
Highest tissue expression: 14 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 14 nTPM
ovary: 14 nTPM
retina: 12 nTPM
pituitary gland: 12 nTPM
vagina: 11 nTPM
cervix: 11 nTPM

Single-cell type

epicardial cells: 14 nCPM
tuft cells: 12 nCPM
esophageal apical cells: 6 nCPM
corticotrophs: 5.3 nCPM
somatotrophs: 5.1 nCPM
medullary thymic epithelial cells: 4.8 nCPM

Immune cell

eosinophil: 1.8 nTPM
MAIT T-cell: 1.7 nTPM
basophil: 1.6 nTPM
gdT-cell: 1.4 nTPM
T-reg: 1.4 nTPM
memory B-cell: 1.3 nTPM

Brain region

cerebellum: 26 nTPM
hypothalamus: 19 nTPM
white matter: 19 nTPM
cerebral cortex: 17 nTPM
basal ganglia: 17 nTPM
choroid plexus: 17 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.4
gnomAD pLI: 0.02
gnomAD missense Z: 0.79
DepMap mean gene effect: 0.06
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of transcription by RNA polymerase II

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF841 as an antibody target. Whether an autoantibody or antibody against ZNF841 could matter depends on whether native ZNF841 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF841 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF841 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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