Seroatlas · Human Serome Atlas

ZNF84

Zinc finger protein 84

Also known as: HPF2, ZNF84_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P51523
Gene
ZNF84
Ensembl
ENSG00000198040
Chromosome
12
Canonical length
738 aa
Protein class
Predicted intracellular proteins, Transcription factors
Subcellular location
Nucleoplasm

OverviewNCBI Gene

Predicted to enable DNA binding activity and zinc ion binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

738 residues, UniProt reviewed canonical sequence.

>P51523|ZNF84
     1  MTMLQESFSF DDLSVDFTQK EWQLLDPSQK NLYKDVMLEN YSSLVSLGYE VMKPDVIFKL
    61  EQGEEPWVGD GEIPSSDSPE VWKVDGNMMW HQDNQDKLKI IKRGHECDAF GKNFNLNMNF
   121  VPLRKSNSEG DLDGLILKHH LDLLIPKGDY GKAESDDFNV FDNFFLHSKP EDTDTWLKYY
   181  DCDKYKESYK KSQIIIYHRN RLGEKLYECS ECRKRFSKKP SLIKHQSRHI RDIAFGCGNC
   241  GKTFPQKSQF ITHHRTHTGE KPYNCSQCGK AFSQKSQLTS HQRTHTGEKP YECGECGKAF
   301  SRKSHLISHW RTHTGEKPYG CNECGRAFSE KSNLINHQRI HTGEKPFECR ECGKAFSRKS
   361  QLVTHHRTHT GTKPFGCSDC RKAFFEKSEL IRHQTIHTGE KPYECSECRK AFRERSSLIN
   421  HQRTHTGEKP HGCIQCGKAF SQKSHLISHQ MTHTGEKPFI CSKCGKAFSR KSQLVRHQRT
   481  HTGEKPYECS ECGKAFSEKL SLTNHQRIHT GEKPYVCSEC GKAFCQKSHL ISHQRTHTGE
   541  KPYECSECGK AFGEKSSLAT HQRTHTGEKP YECRDCEKAF SQKSQLNTHQ RIHTGEKPYE
   601  CSLCRKAFFE KSELIRHLRT HTGEKPYECN ECRKAFREKS SLINHQRIHT GEKPFECSEC
   661  GKAFSRKSHL IPHQRTHTGE KPYGCSECRK AFSQKSQLVN HQRIHTGEKP YRCIECGKAF
   721  SQKSQLINHQ RTHTVKKS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF84 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.44
Highest tissue expression
23 nTPM

Expression across tissuesHPA

Tissue

  • retina: 23 nTPM
  • epididymis: 22 nTPM
  • pituitary gland: 21 nTPM
  • cerebellum: 19 nTPM
  • spinal cord: 17 nTPM
  • ovary: 17 nTPM

Single-cell type

  • lactotrophs: 99 nCPM
  • thyrotrophs: 86 nCPM
  • corticotrophs: 84 nCPM
  • choroid plexus epithelial cells: 83 nCPM
  • somatotrophs: 75 nCPM
  • gonadotrophs: 74 nCPM

Immune cell

  • MAIT T-cell: 12 nTPM
  • naive CD4 T-cell: 12 nTPM
  • memory CD8 T-cell: 10 nTPM
  • NK-cell: 10 nTPM
  • naive CD8 T-cell: 9.9 nTPM
  • memory B-cell: 9.5 nTPM

Brain region

  • white matter: 51 nTPM
  • cerebellum: 44 nTPM
  • choroid plexus: 41 nTPM
  • cerebral cortex: 39 nTPM
  • basal ganglia: 39 nTPM
  • medulla oblongata: 38 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

DepMap mean gene effect
0.01
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZNF84 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF84 as an antibody target. Whether an autoantibody or antibody against ZNF84 could matter depends on whether native ZNF84 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF84 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF84 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ZNF84. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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