Seroatlas · Human Serome Atlas

ZNF839

Zinc finger protein 839

Also known as: C14orf131, ZN839_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A8K0R7
Gene: ZNF839
Ensembl: ENSG00000022976
Chromosome: 14
Canonical length: 811 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Plasma membrane

OverviewNCBI Gene

Predicted to enable zinc ion binding activity. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

811 residues, UniProt reviewed canonical sequence.

>A8K0R7|ZNF839
     1  MLLPTTIQPQ TARKSQLPRG NSCLVGLHIA SPQLLRVQPL VRTEPQSCFL SDLCQPPAQG
    61  FVQRPLPALQ VVPAKRVPAP KAPDEQGSML TPLSASDPLA VTSLSSSSAH PFISNLHTRH
   121  TEKLKKSLKV KTRSGRVSRP PKYKAKDYKF IKTEDLADGH LSDSDDYSEL CVEEDEDQRE
   181  RHALFDLSSC SLRPKSFKCQ TCEKSYIGKG GLARHFKLNP GHGQLDPEMV LSEKASGSTL
   241  RGCTEERTLS LTSLGLSMPA DPCEGGARSC LVTESARGGL QNGQSVDVEE TLPSEPENGA
   301  LLRSERYQGP RRRACSETLA ESRTAVLQQR RAAQLPGGPA AAGEQRASPS KARLKEFLQQ
   361  CDREDLVELA LPQLAQVVTV YEFLLMKVEK DHLAKPFFPA IYKEFEELHK MVKKMCQDYL
   421  SSSGLCSQET LEINNDKVAE SLGITEFLRK KEIHPDNLGP KHLSRDMDGE QLEGASSEKR
   481  EREAAEEGLA SVKRPRREAL SNDTTESLAA NSRGREKPRP LHALAAGFSP PVNVTVSPRS
   541  EESHTTTVSG GNGSVFQAGP QLQALANLEA RRGSIGAALS SRDVSGLPVY AQSGEPRRLT
   601  QAQVAAFPGE NALEHSSDQD TWDSLRSPGF CSPLSSGGGA ESLPPGGPGH AEAGHLGKVC
   661  DFHLNHQQPS PTSVLPTEVA APPLEKILSV DSVAVDCAYR TVPKPGPQPG PHGSLLTEGC
   721  LRSLSGDLNR FPCGMEVHSG QRELESVVAV GEAMAFEISN GSHELLSQGQ KQIFIQTSDG
   781  LILSPPGTIV SQEEDIVTVT DAEGRACGWA R

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF839 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.66
Highest tissue expression: 30 nTPM

Expression across tissuesHPA

Tissue

testis: 30 nTPM
skin: 18 nTPM
skeletal muscle: 17 nTPM
fallopian tube: 16 nTPM
spleen: 15 nTPM
liver: 14 nTPM

Single-cell type

late primary spermatocytes: 54 nCPM
myonuclei: 50 nCPM
sertoli cells: 41 nCPM
proximal tubule cells: 32 nCPM
adipocytes: 31 nCPM
gonadotrophs: 28 nCPM

Immune cell

neutrophil: 1 nTPM
eosinophil: 0.7 nTPM
gdT-cell: 0.7 nTPM
MAIT T-cell: 0.7 nTPM
naive CD4 T-cell: 0.7 nTPM
intermediate monocyte: 0.6 nTPM

Brain region

hypothalamus: 21 nTPM
basal ganglia: 18 nTPM
cerebral cortex: 17 nTPM
medulla oblongata: 17 nTPM
hippocampal formation: 17 nTPM
amygdala: 16 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.8
gnomAD pLI: 0
gnomAD missense Z: 0.92
DepMap mean gene effect: -0.18
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

zinc ion binding

Protein domainsUniProt · Pfam · InterPro

Zinc finger C2H2-type
Domain of unknown function DUF4764
Zinc finger protein 839
Domain of unknown function (DUF4764)

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF839 as an antibody target. Whether an autoantibody or antibody against ZNF839 could matter depends on whether native ZNF839 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF839 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF839 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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