Seroatlas · Human Serome Atlas

ZNF831

Zinc finger protein 831

Also known as: C20orf174, dJ492J12.1, ZN831_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q5JPB2
Gene
ZNF831
Ensembl
ENSG00000124203
Chromosome
20
Canonical length
1677 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable zinc ion binding activity. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1677 residues, UniProt reviewed canonical sequence.

>Q5JPB2|ZNF831
     1  MEVPEPTCPA PPARDQPAPT PGPPGAPGGQ ASPHLTLGPV LLPPEQGLAP PTVFLKALPI
    61  PLYHTVPPGG LQPRAPLVTG SLDGGNVPFI LSPVLQPEGP GPTQVGKPAA PTLTVNIVGT
   121  LPVLSPGLGP TLGSPGKVRN AGKYLCPHCG RDCLKPSVLE KHIRSHTGER PFPCATCGIA
   181  FKTQSNLYKH RRTQTHLNNS RLSSESEGAG GGLLEEGDKA GEPPRPEGRG ESRCQGMHEG
   241  ASERPLSPGA HVPLLAKNLD VRTEAAPCPG SAFADREAPW DSAPMASPGL PAASTQPWRK
   301  LPEQKSPTAG KPCALQRQQA TAAEKPWDAK APEGRLRKCE STDSGYLSRS DSAEQPHAPC
   361  SPLHSLSEHS AESEGEGGPG PGPGVAGAEP GAREAGLELE KKRLEERIAQ LISHNQAVVD
   421  DAQLDNVRPR KTGLSKQGSI DLPTPYTYKD SFHFDIRALE PGRRRAPGPV RSTWTPPDKS
   481  RPLFFHSVPT QLSTTVECVP VTRSNSLPFV EGSRTWLEPR EPRDPWSRTQ KPLSPRPGPA
   541  RLGCRSGLSS TDVPSGHPRA LVRQAAVEDL PGTPIGDALV PAEDTDAKRT AAREAMAGKG
   601  RAGGRKCGQR RLKMFSQEKW QVYGDETFKR IYQKMKASPH GGKKAREVGM GSGAELGFPL
   661  QKEAAGSSGT VPTQDRRTPV HEDISAGATP EPWGNPPALE ASLVTEPTKH GETVARRGDS
   721  DRPRVEEAVS SPALGGRDSP CSGSRSPLVS PNGRLELGWQ MPPAPGPLKG GDVEAPRPVW
   781  PDPKLEGGAR GVGDVQETCL WAQTVLRWPS RGSGEDKLPS ERKKLKVEDL HSWKQPEPVS
   841  AETPGGPTQP ASLSSQKQDA DPGEVPGGSK ESARQVGEPL ESSGASLAAA SVALKRVGPR
   901  DKATPLHPAA PAPAEHPSLA TPPQAPRVLS ALADNAFSPK YLLRLPQAET PLPLPIPWGP
   961  RHSQDSLCSS GWPEERASFV GSGLGTPLSP SPASGPSPGE ADSILEDPSC SRPQDGRKGA
  1021  QLGGDKGDRM ATSRPAAREL PISAPGAPRE ATSSPPTPTC EAHLVQDMEG DSHRIHRLCM
  1081  GSTLARARLS GDVLNPWVPN WELGEPPGNA PEDPSSGPLV GPDPCSPLQP GSFLTALTRP
  1141  QGVPPGWPEL ALSSHSGTSR SHSTRSPHST QNPFPSLKAE PRLTWCCLSR SVPLPAEQKA
  1201  KAASVYLAVH FPGSSLRDEG PNGPPGSNGG WTWTSPGEGG PAQMSKFSYP TVPGVMPQHQ
  1261  VSEPEWKKGL PWRAKMSRGN SKQRKLKINP KRYKGNFLQS CVQLRASRLR TPTWVRRRSR
  1321  HPPALEGLKP CRTPGQTSSE IAGLNLQEEP SCATSESPPC CGKEEKKEGD CRQTLGTLSL
  1381  GTSSRIVREM DKRTVKDISP SAGEHGDCTT HSTAATSGLS LQSDTCLAVV NDVPLPPGKG
  1441  LDLGLLETQL LASQDSVSTD PKPYIFSDAQ RPSSFGSKGT FPHHDIATSV AAVCISLPVR
  1501  TDHIAQEIHS AESRDHSQTA GRTLTSSSPD SKVTEEGRAQ TLLPGRPSSG QRISDSVPLE
  1561  STEKTHLEIP ASGPSSASSH HKEGRHKTFF PSRGQYGCGE MTVPCPSLGS DGRKRQVSGL
  1621  ITRKDSVVPS KPEQPIEIPE APSKSLKKRS LEGMRKQTRV EFSDTSSDDE DRLVIEI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF831 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.71
Highest tissue expression
5.8 nTPM

Expression across tissuesHPA

Tissue

  • lymph node: 5.8 nTPM
  • tonsil: 3.6 nTPM
  • spleen: 2.5 nTPM
  • appendix: 2.2 nTPM
  • small intestine: 1.8 nTPM
  • thymus: 1.4 nTPM

Single-cell type

  • t-cells: 274 nCPM
  • nk-cells: 113 nCPM
  • b-cells: 70 nCPM
  • lymphatic endothelial cells: 46 nCPM
  • innate lymphoid cells: 36 nCPM
  • other brain neurons: 34 nCPM

Immune cell

  • T-reg: 2.2 nTPM
  • gdT-cell: 1.8 nTPM
  • MAIT T-cell: 1.5 nTPM
  • memory CD8 T-cell: 1.5 nTPM
  • NK-cell: 1.2 nTPM
  • memory CD4 T-cell: 1.1 nTPM

Brain region

  • hippocampal formation: 9.4 nTPM
  • cerebral cortex: 8 nTPM
  • amygdala: 7 nTPM
  • basal ganglia: 5.9 nTPM
  • hypothalamus: 4.3 nTPM
  • white matter: 2.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.74
gnomAD pLI
0
gnomAD missense Z
0.54
DepMap mean gene effect
0.04
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF831 as an antibody target. Whether an autoantibody or antibody against ZNF831 could matter depends on whether native ZNF831 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF831 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF831 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ZNF831. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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