Seroatlas · Human Serome Atlas

ZNF83

Zinc finger protein 83

Also known as: FLJ11015, HPF1, ZNF816B, ZNF83_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P51522
Gene: ZNF83
Ensembl: ENSG00000167766
Chromosome: 19
Canonical length: 516 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

516 residues, UniProt reviewed canonical sequence.

>P51522|ZNF83
     1  MHGRKDDAQK QPVKNQLGLN PQSHLPELQL FQAEGKIYKY DHMEKSVNSS SLVSPPQRIS
    61  STVKTHISHT YECNFVDSLF TQKEKANIGT EHYKCSERGK AFHQGLHFTI HQIIHTKETQ
   121  FKCDICGKIF NKKSNLASHQ RIHTGEKPYK CNECGKVFHN MSHLAQHRRI HTGEKPYKCN
   181  ECGKVFNQIS HLAQHQRIHT GEKPYKCNEC GKVFHQISHL AQHRTIHTGE KPYECNKCGK
   241  VFSRNSYLVQ HLIIHTGEKP YRCNVCGKVF HHISHLAQHQ RIHTGEKPYK CNECGKVFSH
   301  KSSLVNHWRI HTGEKPYKCN ECGKVFSHKS SLVNHWRIHT GEKPYKCNEC GKVFSRNSYL
   361  AQHLIIHAGE KPYKCDECDK AFSQNSHLVQ HHRIHTGEKP YKCDECGKVF SQNSYLAYHW
   421  RIHTGEKAYK CNECGKVFGL NSSLAHHRKI HTGEKPFKCN ECGKAFSMRS SLTNHHAIHT
   481  GEKHFKCNEC GKLFRDNSYL VRHQRFHAGK KSNTCN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF83 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.44
Highest tissue expression: 82 nTPM

Expression across tissuesHPA

Tissue

ovary: 82 nTPM
pituitary gland: 71 nTPM
basal ganglia: 71 nTPM
kidney: 70 nTPM
cerebellum: 68 nTPM
prostate: 68 nTPM

Single-cell type

ocular epithelial cells: 360 nCPM
syncytiotrophoblasts: 257 nCPM
granulosa cells: 247 nCPM
proximal tubule cells: 245 nCPM
loop of henle epithelial cells: 229 nCPM
papillary tip epithelial cells: 225 nCPM

Immune cell

memory CD4 T-cell: 5 nTPM
eosinophil: 4.7 nTPM
memory CD8 T-cell: 4.7 nTPM
naive B-cell: 4.7 nTPM
NK-cell: 4.7 nTPM
naive CD4 T-cell: 4.5 nTPM

Brain region

cerebellum: 12 nTPM
white matter: 8.7 nTPM
basal ganglia: 8.5 nTPM
pons: 8.3 nTPM
medulla oblongata: 7.8 nTPM
thalamus: 7.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD missense Z: 0.44
DepMap mean gene effect: 0.02
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of transcription by RNA polymerase II

Molecular functions

Cellular components

nuclear lumen

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF83 as an antibody target. Whether an autoantibody or antibody against ZNF83 could matter depends on whether native ZNF83 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF83 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF83 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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