Seroatlas · Human Serome Atlas

ZNF829

Zinc finger protein 829

Also known as: DKFZp779O175, ZN829_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q3KNS6
Gene
ZNF829
Ensembl
ENSG00000185869
Chromosome
19
Canonical length
432 aa
Protein class
Predicted intracellular proteins, Transcription factors
Subcellular location
Nucleoplasm,Nuclear bodies

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

432 residues, UniProt reviewed canonical sequence.

>Q3KNS6|ZNF829
     1  MPHSPLISIP HVWCHPEEEE RMHDELLQAV SKGPVMFRDV SIDFSQEEWE CLDADQMNLY
    61  KEVMLENFSN LVSVGLSNSK PAVISLLEQG KEPWMVDREL TRGLCSDLES MCETKILSLK
   121  KRHFSQVIIT REDMSTFIQP TFLIPPQKTM SEEKPWECKI CGKTFNQNSQ FIQHQRIHFG
   181  EKHYESKEYG KSFSRGSLVT RHQRIHTGKK PYECKECGKA FSCSSYFSQH QRIHTGEKPY
   241  ECKECGKAFK YCSNLNDHQR IHTGEKPYEC KVCGKAFTKS SQLFLHLRIH TGEKPYECKE
   301  CGKAFTQHSR LIQHQRMHTG EKPYECKQCG KAFNSASTLT NHHRIHAGEK LYECEECRKA
   361  FIQSSELIQH QRIHTDEKPY ECNECGKAFN KGSNLTRHQR IHTGEKPYDC KECGKAFGSR
   421  SDLIRHEGIH TG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF829 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.43
Highest tissue expression
6.2 nTPM

Expression across tissuesHPA

Tissue

  • testis: 6.2 nTPM
  • ovary: 2.1 nTPM
  • breast: 1.9 nTPM
  • parathyroid gland: 1.8 nTPM
  • retina: 1.8 nTPM
  • skin: 1.7 nTPM

Single-cell type

  • early spermatids: 336 nCPM
  • late primary spermatocytes: 78 nCPM
  • late spermatids: 66 nCPM
  • cardiomyocytes: 38 nCPM
  • epicardial cells: 21 nCPM
  • adipocytes: 18 nCPM

Immune cell

  • naive CD8 T-cell: 1.5 nTPM
  • MAIT T-cell: 1.4 nTPM
  • memory CD8 T-cell: 1.4 nTPM
  • naive CD4 T-cell: 1.4 nTPM
  • basophil: 1.3 nTPM
  • naive B-cell: 1.1 nTPM

Brain region

  • cerebellum: 8.2 nTPM
  • cerebral cortex: 6.2 nTPM
  • hypothalamus: 6.1 nTPM
  • white matter: 6.1 nTPM
  • basal ganglia: 5.7 nTPM
  • amygdala: 5.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.22
gnomAD pLI
0
gnomAD missense Z
1.03
DepMap mean gene effect
0.04
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZNF829 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF829 as an antibody target. Whether an autoantibody or antibody against ZNF829 could matter depends on whether native ZNF829 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF829 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF829 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ZNF829. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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