Seroatlas · Human Serome Atlas

ZNF823

Zinc finger protein 823

Also known as: HSZFP36, ZN823_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P16415
Gene
ZNF823
Ensembl
ENSG00000197933
Chromosome
19
Canonical length
610 aa
Protein class
Predicted intracellular proteins, Transcription factors

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

610 residues, UniProt reviewed canonical sequence.

>P16415|ZNF823
     1  MDSVAFEDVA VNFTQEEWAL LGPSQKSLYR NVMQETIRNL DCIEMKWEDQ NIGDQCQNAK
    61  RNLRSHTCEI KDDSQCGETF GQIPDSIVNK NTPRVNPCDS GECGEVVLGH SSLNCNIRVD
   121  TGHKSCEHQE YGEKPYTHKQ RGKAISHQHS FQTHERPPTG KKPFDCKECA KTFSSLGNLR
   181  RHMAAHHGDG PYKCKLCGKA FVWPSLFHLH ERTHTGEKPY ECKQCSKAFP FYSSYLRHER
   241  IHTGEKAYEC KQCSKAFPDY STYLRHERTH TGEKPYKCTQ CGKAFSCYYY TRLHERTHTG
   301  EQPYACKQCG KTFYHHTSFR RHMIRHTGDG PHKCKICGKG FDCPSSVRNH ETTHTGEKPY
   361  ECKQCGKVLS HSSSFRSHMI THTGDGPQKC KICGKAFGCP SLFQRHERTH TGEKPYQCKQ
   421  CGKAFSLAGS LRRHEATHTG VKPYKCQCGK AFSDLSSFQN HETTHTGEKP YECKECGKAF
   481  SCFKYLSQHK RTHTVEKPYE CKTCRKAFSH FSNLKVHERI HSGEKPYECK ECGKAFSWLT
   541  CLLRHERIHT GEKPYECLQC GKAFTRSRFL RGHEKTHTGE KLYECKECGK ALSSLRSLHR
   601  HKRTHWKDTL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF823 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.45
Highest tissue expression
8 nTPM

Expression across tissuesHPA

Tissue

  • esophagus: 8 nTPM
  • breast: 6.9 nTPM
  • liver: 5.9 nTPM
  • kidney: 5.7 nTPM
  • parathyroid gland: 5.7 nTPM
  • colon: 5.6 nTPM

Single-cell type

  • esophageal apical cells: 125 nCPM
  • migrating cytotrophoblasts: 88 nCPM
  • syncytiotrophoblasts: 85 nCPM
  • cytotrophoblasts: 82 nCPM
  • extravillous trophoblasts: 63 nCPM
  • colonocytes: 44 nCPM

Immune cell

  • eosinophil: 10 nTPM
  • naive CD4 T-cell: 5.9 nTPM
  • NK-cell: 5.3 nTPM
  • naive CD8 T-cell: 4.3 nTPM
  • MAIT T-cell: 4.2 nTPM
  • memory CD4 T-cell: 3.4 nTPM

Brain region

  • cerebellum: 29 nTPM
  • basal ganglia: 11 nTPM
  • white matter: 10 nTPM
  • thalamus: 10 nTPM
  • cerebral cortex: 9.8 nTPM
  • pons: 9.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.99
gnomAD pLI
0.38
gnomAD missense Z
1.82
DepMap mean gene effect
0.06
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF823 as an antibody target. Whether an autoantibody or antibody against ZNF823 could matter depends on whether native ZNF823 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF823 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF823 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ZNF823. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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