Seroatlas · Human Serome Atlas

ZNF821

Zinc finger protein 821

Also known as: ZN821_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O75541
Gene: ZNF821
Ensembl: ENSG00000102984
Chromosome: 16
Canonical length: 412 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nuclear speckles

OverviewNCBI Gene

This gene encodes a protein with two C2H2 zinc finger motifs and a score-and-three (23)-amino acid peptide repeat (STPR) domain. The STPR domain of the encoded protein binds to double stranded DNA and may also contain a nuclear localization signal, suggesting that this protein interacts with chromosomal DNA. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]

Canonical amino-acid sequenceUniProt

412 residues, UniProt reviewed canonical sequence.

>O75541|ZNF821
     1  MSRRKQTNPN KVHWDQVFAG LEEQARQAMM KTDFPGDLGS QRQAIQQLRD QDSSSSDSEG
    61  DEEETTQDEV SSHTSEEDGG VVKVEKELEN TEQPVGGNEV VEHEVTGNLN SDPLLELCQC
   121  PLCQLDCGSR EQLIAHVYQH TAAVVSAKSY MCPVCGRALS SPGSLGRHLL IHSEDQRSNC
   181  AVCGARFTSH ATFNSEKLPE VLNMESLPTV HNEGPSSAEG KDIAFSPPVY PAGILLVCNN
   241  CAAYRKLLEA QTPSVRKWAL RRQNEPLEVR LQRLERERTA KKSRRDNETP EEREVRRMRD
   301  REAKRLQRMQ ETDEQRARRL QRDREAMRLK RANETPEKRQ ARLIREREAK RLKRRLEKMD
   361  MMLRAQFGQD PSAMAALAAE MNFFQLPVSG VELDSQLLGK MAFEEQNSSS LH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF821 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.53
Highest tissue expression: 25 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 25 nTPM
testis: 20 nTPM
retina: 8.6 nTPM
cerebral cortex: 8.1 nTPM
pituitary gland: 8.1 nTPM
epididymis: 7.1 nTPM

Single-cell type

late primary spermatocytes: 198 nCPM
enterocytes: 194 nCPM
early spermatids: 184 nCPM
pituitary stem cells: 133 nCPM
retinal ganglion cells: 100 nCPM
retinal amacrine cells: 93 nCPM

Immune cell

naive B-cell: 14 nTPM
memory B-cell: 9.5 nTPM
T-reg: 5.7 nTPM
memory CD4 T-cell: 2.1 nTPM
gdT-cell: 2 nTPM
MAIT T-cell: 1.8 nTPM

Brain region

cerebellum: 18 nTPM
hypothalamus: 11 nTPM
cerebral cortex: 9.8 nTPM
basal ganglia: 8.9 nTPM
pons: 8.3 nTPM
medulla oblongata: 8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.68
gnomAD pLI: 0
gnomAD missense Z: 1.99
DepMap mean gene effect: 0.1
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of transcription by RNA polymerase II

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF821 as an antibody target. Whether an autoantibody or antibody against ZNF821 could matter depends on whether native ZNF821 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF821 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF821 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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