Seroatlas · Human Serome Atlas

ZNF816

Zinc finger protein 816

Also known as: ZN816_HUMAN, ZNF816A

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q0VGE8
Gene: ZNF816
Ensembl: ENSG00000180257
Chromosome: 19
Canonical length: 651 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins, Transcription factors
Subcellular location: Nucleoli rim

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in membrane. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

651 residues, UniProt reviewed canonical sequence.

>Q0VGE8|ZNF816
     1  MLREEATKKS KEKEPGMALP QGRLTFRDVA IEFSLEEWKC LNPAQRALYR AVMLENYRNL
    61  EFVDSSLKSM MEFSSTRHSI TGEVIHTGTL QRHKSHHIGD FCFPEMKKDI HHFEFQWQEV
   121  ERNGHEAPMT KIKKLTGSTD RSDHRHAGNK PIKDQLGLSF HSHLPELHMF QTKGKISNQL
   181  DKSIGASSAS ESQRISCRLK THISNKYGKN FLHSSFTQIQ EICMREKPCQ SNECGKAFNY
   241  SSLLRRHHIT HSREREYKCD VCGKIFNQKQ YIVYHHRCHT GEKTYKCNEC GKTFTQMSSL
   301  VCHRRLHTGE KPYKCNECGK TFSEKSSLRC HRRLHTGEKP YKCNECGKTF GRNSALVIHK
   361  AIHTGEKPYK CNECGKTFSQ KSSLQCHHIL HTGEKPYKCE ECDNVYIRRS HLERHRKIHT
   421  GEGSYKCKVC DKVFRSDSYL AEHQRVHTGE KPYKCNKCGR SFSRKSSLQY HHTLHTGEKP
   481  YTCNECGKVF SRRENLARHH RLHAGEKPYK CEECDKVFSR RSHLERHRRI HTGEKPYKCK
   541  VCDKAFRSDS CLANHTRVHT GEKPYKCNKC AKVFNQKGIL AQHQRVHTGE KPYKCNECGK
   601  VFNQKASLAK HQRVHTAEKP YKCNECGKAF TGQSTLIHHQ AIHGCRETLQ M

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF816 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.48
Highest tissue expression: 12 nTPM

Expression across tissuesHPA

Tissue

prostate: 12 nTPM
fallopian tube: 11 nTPM
rectum: 9.3 nTPM
stomach: 9.3 nTPM
cervix: 9 nTPM
thymus: 9 nTPM

Single-cell type

medullary thymic epithelial cells: 7.2 nCPM
microglia: 4.8 nCPM
ependymal cells: 2.3 nCPM
choroid plexus epithelial cells: 2.2 nCPM
astrocytes: 1.8 nCPM
bergmann glia: 1.7 nCPM

Immune cell

NK-cell: 21 nTPM
MAIT T-cell: 19 nTPM
naive CD4 T-cell: 19 nTPM
eosinophil: 17 nTPM
naive CD8 T-cell: 14 nTPM
gdT-cell: 14 nTPM

Brain region

cerebellum: 16 nTPM
choroid plexus: 11 nTPM
medulla oblongata: 9.1 nTPM
hypothalamus: 9 nTPM
white matter: 8.8 nTPM
pons: 8.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.92
gnomAD pLI: 0
gnomAD missense Z: -0.03
DepMap mean gene effect: -0.02
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF816 as an antibody target. Whether an autoantibody or antibody against ZNF816 could matter depends on whether native ZNF816 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF816 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF816 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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