Seroatlas · Human Serome Atlas

ZNF814

Zinc finger protein 814

Also known as: ZN814_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: B7Z6K7
Gene: ZNF814
Ensembl: ENSG00000204514
Chromosome: 19
Canonical length: 855 aa
Protein class: Cancer-related genes, Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Predicted to enable zinc ion binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

855 residues, UniProt reviewed canonical sequence.

>B7Z6K7|ZNF814
     1  MAAAATLRLS AQGTVTFEDV AVNFTWEEWN LLSEAQRCLY RDVTLENLAL ISSLGCWCGV
    61  EDEAAPSKQS IYIQRETQVR TPMAGVSPKK AHPCEMCGPI LGDILHVADH QGTHHKQKLH
   121  RCEAWGNKLY DSGNFHQHQN EHIGEKPYRG SVEEALFAKR CKLHVSGESS VFSESGKDFL
   181  PRSGLLQQEA SHTGEKSNSK TECVSPIQCG GAHYSCGESM KHFSTKHILS QHQRLLTREE
   241  CYVCCECGKS FSKYASLSNH QRVHTEKKHE CGECGKSFSK YVSFSNHQRV HTEKKHECGE
   301  CGKSFSKYVS FSNHQRVHTG KRPYECGECG KSFSKYASFS NHQRVHTEKK HYECGECGKS
   361  FSKYVSFSNH QRVHTGKRPY ECGECGKSFS KYASFSNHQR VHTDKKHYEC GECGKSFSQK
   421  SSLIQHQRFH TGEKPYGCEE CGKSFSSEGH LRSHQRVHAG ERPFKCGECV KSFSHKRSLV
   481  HHQRVHSGER PYQCGECGKS FSQKGNLVLH QRVHTGARPY ECGECGKSFS SKGHLRNHQQ
   541  IHTGDRLYEC GECGKSFSHK GTLILHQRVH PRERSYGCGE CGKSFSSIGH LRSHQRVHTG
   601  ERPYECGECG KSFSHKRSLV HHQRMHTGER PYKCGDCGKS FNEKGHLRNH QRVHTTERPF
   661  KCGECGKCFS HKGNLILHQH GHTGERPYVC RECGKLFKKK SHLLVHQRIH NGEKPYACEA
   721  CQKFFRNKYQ LIAHQRVHTG ERPYECNDCG KSFTHSSTFC VHKRIHTGEK PYECSECGKS
   781  FAESSSFTKH KRVHTGEKPY ECSECGKSFA ESSSLTKHKR VHTGEKPYKC EKCGKLFNKK
   841  SHLLVHQSSH WRKAI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF814 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.46
Highest tissue expression: 17 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 17 nTPM
kidney: 15 nTPM
thyroid gland: 14 nTPM
pituitary gland: 14 nTPM
adrenal gland: 14 nTPM
retina: 13 nTPM

Single-cell type

cardiomyocytes: 211 nCPM
epicardial cells: 155 nCPM
myonuclei: 140 nCPM
paneth cells: 101 nCPM
granulosa cells: 96 nCPM
adipocytes: 83 nCPM

Immune cell

naive B-cell: 39 nTPM
memory B-cell: 37 nTPM
plasmacytoid DC: 28 nTPM
NK-cell: 25 nTPM
naive CD4 T-cell: 22 nTPM
naive CD8 T-cell: 19 nTPM

Brain region

cerebellum: 84 nTPM
hippocampal formation: 52 nTPM
amygdala: 52 nTPM
cerebral cortex: 49 nTPM
choroid plexus: 49 nTPM
medulla oblongata: 47 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.72
gnomAD pLI: 0.04
gnomAD missense Z: -0.92
DepMap mean gene effect: 0.1
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of transcription by RNA polymerase II

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF814 as an antibody target. Whether an autoantibody or antibody against ZNF814 could matter depends on whether native ZNF814 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF814 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF814 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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