ZNF813

Protein identityUniProt · HPA

UniProt accession

Q6ZN06

Gene

ZNF813

Ensembl

ENSG00000198346

Chromosome

19

Canonical length

617 aa

Protein class

Predicted intracellular proteins, Transcription factors

Subcellular location

Vesicles

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

617 residues, UniProt reviewed canonical sequence.

>Q6ZN06|ZNF813
     1  MALPQGLLTF RDVAIEFSQE EWKCLDPAQR TLYRDVMLEN YRNLVSLDIS SKCMMKEFSS
    61  TAQGNREVIH TGTLQRHESH HTGDFRFQEI DKDIHNLEFQ WQEDERNSHE APMTEIKKLT
   121  GSADRYDQRH AGNKPIKDQL GSSFHSHLPE LHMFQTQGKI GNQVEKSIND ASSISTSQRI
   181  SCRPKTHISN NYGNNFRNSS LLTQKQEVHM REKSFQCNES GKAFNYSSLL RKHQIIHLGE
   241  KQYKCDVCGK VFNRKRNLVC HRRCHTGEKP YRCNECGKTF SQTYSLTCHR RLHTGEKPYK
   301  CEECDKAFSF KSNLKRHRRI HAGEKPYKCN ECGKTFSQTS SLTCHRRLHT GEKPFKCNEC
   361  GKTFSRKSSL TCHHRLHTGE KPYKCNECGK TFSQELTLKC HRRLHTGEKP YKCNECGKVF
   421  NKKANLARHH RLHSGEKPYK CTECVKTFSR NSALVIHKAI HIGEKRYKCN ECGKTFSRIS
   481  ALVIHTAIHT GEKPYKCNEC GKGFNRKTHL ACHHRLHTGE KPYKCNECGK VFNRKTHLAH
   541  HHRLHTGDKP YKCNECGKVF NQKAHLARHH RLHTGEKPYK CNECGKVFNQ KANLARHHRL
   601  HTGEKPYKFN ECGKAFN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF813 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.47

Highest tissue expression

4.6 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.92

gnomAD pLI

0.64

gnomAD missense Z

-0.65

DepMap mean gene effect

0.07

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• regulation of transcription by RNA polymerase II

Molecular functions

• DNA-binding transcription factor activity, RNA polymerase II-specific
• RNA polymerase II cis-regulatory region sequence-specific DNA binding
• zinc ion binding

Cellular components

• nucleus

Protein domainsUniProt · Pfam · InterPro

• Krueppel-associated box
• Zinc finger C2H2-type
• Krueppel-associated box domain superfamily
• Zinc finger C2H2 superfamily
• Zinc finger, C2H2 type
• KRAB box
• C2H2-type zinc finger

KeywordsUniProt

• DNA-binding
• Metal-binding
• Nucleus
• Repeat
• Transcription
• Transcription regulation
• Zinc
• Zinc-finger

InteractionsUniProt · HPA

Protein binding partners of ZNF813 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• TRIM28