Seroatlas · Human Serome Atlas

ZNF81

Zinc finger protein 81

Also known as: HFZ20, MRX45, ZNF81_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P51508
Gene: ZNF81
Ensembl: ENSG00000197779
Chromosome: X
Canonical length: 661 aa
Protein class: Disease related genes, Predicted intracellular proteins, Transcription factors

OverviewNCBI Gene

This gene encodes a protein that likely functions as a transcription factor. The protein contains an N-terminal KRAB domain and several C2H2-type zinc finger motifs. Mutations in this gene cause an X-linked form of intellectual disability (MRX45). Microduplication of a region of chromosome X including this gene has also been associated with other forms of intellectual disability. [provided by RefSeq, Jul 2017]

Canonical amino-acid sequenceUniProt

661 residues, UniProt reviewed canonical sequence.

>P51508|ZNF81
     1  MPANEDAPQP GEHGSACEVS VSFEDVTVDF SREEWQQLDS TQRRLYQDVM LENYSHLLSV
    61  GFEVPKPEVI FKLEQGEGPW TLEGEAPHQS CSDGKFGIKP SQRRISGKST FHSEMEGEDT
   121  RDDSLYSILE ELWQDAEQIK RCQEKHNKLL SRTTFLNKKI LNTEWDYEYK DFGKFVHPSP
   181  NLILSQKRPH KRDSFGKSFK HNLDLHIHNK SNAAKNLDKT IGHGQVFTQN SSYSHHENTH
   241  TGVKFCERNQ CGKVLSLKHS LSQNVKFPIG EKANTCTEFG KIFTQRSHFF APQKIHTVEK
   301  PHELSKCVNV FTQKPLLSIY LRVHRDEKLY ICTKCGKAFI QNSELIMHEK THTREKPYKC
   361  NECGKSFFQV SSLLRHQTTH TGEKLFECSE CGKGFSLNSA LNIHQKIHTG ERHHKCSECG
   421  KAFTQKSTLR MHQRIHTGER SYICTQCGQA FIQKAHLIAH QRIHTGEKPY ECSDCGKSFP
   481  SKSQLQMHKR IHTGEKPYIC TECGKAFTNR SNLNTHQKSH TGEKSYICAE CGKAFTDRSN
   541  FNKHQTIHTG EKPYVCADCG RAFIQKSELI THQRIHTTEK PYKCPDCEKS FSKKPHLKVH
   601  QRIHTGEKPY ICAECGKAFT DRSNFNKHQT IHTGDKPYKC SDCGKGFTQK SVLSMHRNIH
   661  T

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF81 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.49
Highest tissue expression: 4 nTPM

Expression across tissuesHPA

Tissue

retina: 4 nTPM
skin: 3.4 nTPM
heart muscle: 3.3 nTPM
parathyroid gland: 3.3 nTPM
bone marrow: 3 nTPM
rectum: 2.7 nTPM

Single-cell type

cardiomyocytes: 78 nCPM
adipocytes: 76 nCPM
fibro-adipogenic progenitors: 63 nCPM
thyrotrophs: 55 nCPM
proximal tubule cells: 53 nCPM
lactotrophs: 53 nCPM

Immune cell

eosinophil: 3 nTPM
NK-cell: 2.7 nTPM
intermediate monocyte: 1.8 nTPM
neutrophil: 1.8 nTPM
myeloid DC: 1.6 nTPM
classical monocyte: 1.5 nTPM

Brain region

hypothalamus: 20 nTPM
white matter: 20 nTPM
basal ganglia: 19 nTPM
medulla oblongata: 18 nTPM
thalamus: 18 nTPM
cerebral cortex: 18 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.51
gnomAD pLI: 0.55
gnomAD missense Z: 1.42
DepMap mean gene effect: 0.08
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of transcription by RNA polymerase II

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF81 as an antibody target. Whether an autoantibody or antibody against ZNF81 could matter depends on whether native ZNF81 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF81 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF81 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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