Seroatlas · Human Serome Atlas

ZNF808

Zinc finger protein 808

Also known as: ZN808_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N4W9
Gene: ZNF808
Ensembl: ENSG00000198482
Chromosome: 19
Canonical length: 903 aa
Protein class: Predicted intracellular proteins, Transcription factors

OverviewNCBI Gene

Enables transcription cis-regulatory region binding activity. Involved in cell differentiation; negative regulation of gene expression; and pancreas development. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

903 residues, UniProt reviewed canonical sequence.

>Q8N4W9|ZNF808
     1  MLREEAAQKR KGKESGMALP QGRLTFRDVA IEFSLAEWKF LNPAQRALYR EVMLENYRNL
    61  EAVDISSKHM MKEVLSTGQG NREVIHTGTL QRHQSYHIGD FCFQEIEKEI HNIEFQCQED
   121  ERNGHEAPTT KIKKLTGSTD QHDHRHAGNK PIKDQLGSSF YSHLPELHIF QIKGEIANQL
   181  EKSTSDASSV STSQRISCRP QIHISNNYGN NPLNSSLLPQ KQEVHMREKS FPCNESGKAF
   241  NCSSLLRKHQ IPHLGDKQYK CDVCGKLFNH KQYLACHRRC HTGEKPYKCK ECGKSFSYKS
   301  SLTCHHRLHT GVKPYKCNEC GKVFRQNSAL VIHKAIHTGE KPYKCNECGK AFNQQSHLSR
   361  HQRLHTGVKP YKCKICEKAF ACHSYLANHT RIHSGEKTYK CNECGKAFNH QSSLARHHIL
   421  HTGEKPYKCE ECDKVFSQKS TLERHKRIHT GEKPYKCKVC DTAFTCNSQL ARHRRIHTGE
   481  KTYKCNECRK TFSRRSSLLC HRRLHSGEKP YKCNQCGNTF RHRASLVYHR RLHTLEKSYK
   541  CTVCNKVFMR NSVLAVHTRI HTAKKPYKCN ECGKAFNQQS HLSRHRRLHT GEKPYKCEAC
   601  DKVFGQKSAL ESHKRIHTGE KPYRCQVCDT AFTWNSQLAR HTRIHTGEKT YKCNECGKTF
   661  SYKSSLVWHR RLHGGEKSYK CKVCDKAFVC RSYVAKHTRI HSGMKPYKCN ECSKTFSNRS
   721  SLVCHRRIHS GEKPYKCSEC SKTFSQKATL LCHRRLHSGE KPYKCNDCGN TFRHWSSLVY
   781  HRRLHTGEKS YKCTVCDKAF VRNSYLARHI RIHTAEKPYK CNECGKAFNE QSHLSRHHRI
   841  HTGEKPYKCE ACDKVFSRKS HLKRHRIIHT GEKPYKCNEC GKAFSDRSTL IHHQAIHGIG
   901  KFD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF808 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.45
Highest tissue expression: 6.8 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 6.8 nTPM
tongue: 6 nTPM
thyroid gland: 5.1 nTPM
parathyroid gland: 4.3 nTPM
retina: 4.2 nTPM
spleen: 3.9 nTPM

Single-cell type

cardiomyocytes: 81 nCPM
distal convoluted tubule cells: 33 nCPM
myonuclei: 32 nCPM
cone photoreceptor cells: 31 nCPM
renal collecting duct intercalated cells: 30 nCPM
epicardial cells: 30 nCPM

Immune cell

basophil: 13 nTPM
neutrophil: 11 nTPM
eosinophil: 10 nTPM
NK-cell: 7.4 nTPM
memory B-cell: 7.1 nTPM
MAIT T-cell: 6.5 nTPM

Brain region

choroid plexus: 30 nTPM
midbrain: 21 nTPM
basal ganglia: 20 nTPM
pons: 20 nTPM
cerebellum: 20 nTPM
white matter: 19 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ZNF808.

Disease | GeneticClinVar

9 pathogenic / likely-pathogenic of 184 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Pancreatic agenesis 3
See cases
Neurodevelopmental disorder with microcephaly, epilepsy, and brain atrophy
Permanent neonatal diabetes mellitus

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.21
gnomAD pLI: 0.29
gnomAD missense Z: -0.96
DepMap mean gene effect: 0.03
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF808 as an antibody target. Whether an autoantibody or antibody against ZNF808 could matter depends on whether native ZNF808 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF808 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF808 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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