ZNF805

Protein identityUniProt · HPA

UniProt accession

Q5CZA5

Gene

ZNF805

Ensembl

ENSG00000204524

Chromosome

19

Canonical length

627 aa

Protein class

Predicted intracellular proteins, Transcription factors

Subcellular location

Nucleoplasm

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

627 residues, UniProt reviewed canonical sequence.

>Q5CZA5|ZNF805
     1  MAMALTDPAQ VSVTFDDVAV TFTQEEWGQL DLAQRTLYQE VMLENCGLLV SLGCPVPRPE
    61  LIYHLEHGQE PWTRKEDLSQ GTCPGDKGKP KSTEPTTCEL ALSEGISFWG QLTQGASGDS
   121  QLGQPKDQDG FSEMQGERLR PGLDSQKEKL PGKMSPKHDG LGTADSVCSR IIQDRVSLGD
   181  DVHDCDSHGS GKNPVIQEEE NIFKCNECEK VFNKKRLLAR HERIHSGVKP YECTECGKTF
   241  SKSTYLLQHH MVHTGEKPYK CMECGKAFNR KSHLTQHQRI HSGEKPYKCS ECGKAFTHRS
   301  TFVLHNRSHT GEKPFVCKEC GKAFRDRPGF IRHYIIHSGE NPYECFECGK VFKHRSYLMW
   361  HQQTHTGEKP YECSECGKAF CESAALIHHY VIHTGEKPFE CLECGKAFNH RSYLKRHQRI
   421  HTGEKPYVCS ECGKAFTHCS TFILHKRAHT GEKPFECKEC GKAFSNRADL IRHFSIHTGE
   481  KPYECMECGK AFNRRSGLTR HQRIHSGEKP YECIECGKTF CWSTNLIRHS IIHTGEKPYE
   541  CSECGKAFSR SSSLTQHQRM HTGRNPISVT DVGRPFTSGQ TSVNIQELLL GKNFLNVTTE
   601  ENLLQEEASY MASDRTYQRE TPQVSSL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF805 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.48

Highest tissue expression

6.3 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.47

gnomAD pLI

0.39

gnomAD missense Z

1.51

DepMap mean gene effect

0.08

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• regulation of transcription by RNA polymerase II

Molecular functions

• DNA-binding transcription factor activity, RNA polymerase II-specific
• RNA polymerase II cis-regulatory region sequence-specific DNA binding
• zinc ion binding

Cellular components

• nucleus

Protein domainsUniProt · Pfam · InterPro

• Krueppel-associated box
• Zinc finger C2H2-type
• Krueppel-associated box domain superfamily
• Zinc finger C2H2 superfamily
• Zinc finger, C2H2 type
• KRAB box
• Zinc-finger double domain

KeywordsUniProt

• DNA-binding
• Metal-binding
• Nucleus
• Repeat
• Transcription
• Transcription regulation
• Zinc
• Zinc-finger

InteractionsUniProt · HPA

Protein binding partners of ZNF805 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• TRIM28