Seroatlas · Human Serome Atlas

ZNF804B

Zinc finger protein 804B

Also known as: FLJ32110, Z804B_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A4D1E1
Gene: ZNF804B
Ensembl: ENSG00000182348
Chromosome: 7
Canonical length: 1349 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable zinc ion binding activity. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1349 residues, UniProt reviewed canonical sequence.

>A4D1E1|ZNF804B
     1  MACYLVISSR HLSNGHYRGI KGVFRGPLCK NGSPSPDFAE KKSTAKALED VKANFYCELC
    61  DKQYHKHQEF DNHINSYDHA HKQRLKELKQ REFARNVASK SWKDEKKQEK ALKRLHQLAE
   121  LRQQSECVSG NGPAYKAPRV AIEKQLQQGI FPIKNGRKVS CMKSALLLKG KNLPRIISDK
   181  QRSTMPNRHQ LQSDRRCLFG NQVLQTSSDL SNANHRTGVS FTFSKKVHLK LESSASVFSE
   241  NTEETHDCNK SPIYKTKQTA DKCKCCRFAN KDTHLTKEKE VNISPSHLES VLHNTISINS
   301  KILQDKHDSI DETLEDSIGI HASFSKSNIH LSDVDFTPTS REKETRNTLK NTLENCVNHP
   361  CQANASFSPP NIYNHSDARI SECLDEFSSL EPSEQKSTVH LNPNSRIENR EKSLDKTERV
   421  SKNVQRLVKE ACTHNVASKP LPFLHVQSKD GHTTLQWPTE LLLFTKTEPC ISYGCNPLYF
   481  DFKLSRNTKE DHNLEDLKTE LGKKPLELKT KRESQVSGLT EDQQKLIQED YQYPKPKTMI
   541  ANPDWEKFQR KYNLDYSDSE PNKSEYTFSA NDLEMKNPKV PLYLNTSLKD CAGKNNSSEN
   601  KLKEASRAHW QGCRKAVLND IDEDLSFPSY ISRFKKHKLI PCSPHLEFED ERQFNCKSSP
   661  CTVGGHSDHG KDFSVILKSN HISMTSKVSG CGNQRYKRYS PQSCLSRYSS SLDTSPSSMS
   721  SLRSTCSSHR FNGNSRGNLL CFHKREHHSV ERHKRKCLKH NCFYLSDDIT KSSQMQSEPQ
   781  KERNCKLWES FKNEKYSKRR YCHCRERQKL GKNQQQFSGL KSTRIIYCDS NSQISCTGSS
   841  KKPPNCQGTQ HDRLDSYSIE KMYYLNKSKR NQESLGSPHI CDLGKVRPMK CNSGNISCLL
   901  KNCSSGPSET TESNTAEGER TPLTAKILLE RVQAKKCQEQ SSNVEISSNS CKSELEAPSQ
   961  VPCTIQLAPS GCNRQALPLS EKIQYASESR NDQDSAIPRT TEKDKSKSSH TNNFTILADT
  1021  DCDNHLSKGI IHLVTESQSL NIKRDATTKE QSKPLISEIQ PFIQSCDPVP NEFPGAFPSN
  1081  KYTGVTDSTE TQEDQINLDL QDVSMHINHV EGNINSYYDR TMQKPDKVED GLEMCHKSIS
  1141  PPLIQQPITF SPDEIDKYKI LQLQAQQHMQ KQLLSKHLRV LPAAGPTAFS PASTVQTVPV
  1201  HQHTSITTIH HTFLQHFAVS ASLSSHSSHL PIAHLHPLSQ AHFSPISFST LTPTIIPAHP
  1261  TFLAGHPLHL VAATPFHPSH ITLQPLPPTA FIPTLFGPHL NPATTSIIHL NPLIQPVFQG
  1321  QDFCHHSCSS QMQQLNEVKE ALNVSTHLN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF804B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.66
Highest tissue expression: 3.7 nTPM

Expression across tissuesHPA

Tissue

thyroid gland: 3.7 nTPM
kidney: 0.8 nTPM
retina: 0.8 nTPM
pancreas: 0.3 nTPM
cerebral cortex: 0.1 nTPM
placenta: 0.1 nTPM

Single-cell type

retinal bipolar cells: 1,666 nCPM
proximal tubule cells: 491 nCPM
hematopoietic stem cells: 395 nCPM
thyrotrophs: 349 nCPM
brain inhibitory neurons: 324 nCPM
megakaryocyte-erythroid progenitors: 319 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 8.7 nTPM
thalamus: 3.8 nTPM
hypothalamus: 3.6 nTPM
midbrain: 3.5 nTPM
white matter: 3.3 nTPM
pons: 3.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1
gnomAD pLI: 0
gnomAD missense Z: -0.75
DepMap mean gene effect: -0.02
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

zinc ion binding

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF804B as an antibody target. Whether an autoantibody or antibody against ZNF804B could matter depends on whether native ZNF804B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF804B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF804B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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