Seroatlas · Human Serome Atlas

ZNF804A

Zinc finger protein 804A

Also known as: C2orf10, Z804A_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q7Z570
Gene: ZNF804A
Ensembl: ENSG00000170396
Chromosome: 2
Canonical length: 1209 aa
Protein class: Predicted intracellular proteins
Subcellular location: Endoplasmic reticulum

OverviewNCBI Gene

The protein encoded by this gene is a zinc finger binding protein. Polymorphisms in this gene, especially rs1344706, are thought to confer increased susceptibility to schizophrenia, bipolar disorder, and heroin addiciton. [provided by RefSeq, Nov 2015]

Canonical amino-acid sequenceUniProt

1209 residues, UniProt reviewed canonical sequence.

>Q7Z570|ZNF804A
     1  MECYYIVISS THLSNGHFRN IKGVFRGPLS KNGNKTLDYA EKENTIAKAL EDLKANFYCE
    61  LCDKQYYKHQ EFDNHINSYD HAHKQRLKEL KQREFARNVA SKSRKDERKQ EKALQRLHKL
   121  AELRKETVCA PGSGPMFKST TVTVRENCNE ISQRVVVDSV NNQQDFKYTL IHSEENTKDA
   181  TTVAEDPESA NNYTAKNNQV GDQAQGIHRH KIGFSFAFPK KASVKLESSA AAFSEYSDDA
   241  SVGKGFSRKS RFVPSACHLQ QSSPTDVLLS SEEKTNSFHP PEAMCRDKET VQTQEIKEVS
   301  SEKDALLLPS FCKFQLQLSS DADNCQNSVP LADQIPLESV VINEDIPVSG NSFELLGNKS
   361  TVLDMSNDCI SVQATTEENV KHNEASTTEV ENKNGPETLA PSNTEEVNIT IHKKTNFCKR
   421  QCEPFVPVLN KHRSTVLQWP SEMLVYTTTK PSISYSCNPL CFDFKSTKVN NNLDKNKPDL
   481  KDLCSQQKQE DICMGPLSDY KDVSTEGLTD YEIGSSKNKC SQVTPLLADD ILSSSCDSGK
   541  NENTGQRYKN ISCKIRETEK YNFTKSQIKQ DTLDEKYNKI RLKETHEYWF HKSRRKKKRK
   601  KLCQHHHMEK TKESETRCKM EAENSYTENA GKYLLEPISE KQYLAAEQLL DSHQLLDKRP
   661  KSESISLSDN EEMCKTWNTE YNTYDTISSK NHCKKNTILL NGQSNATMIH SGKHNLTYSR
   721  TYCCWKTKMS SCSQDHRSLV LQNDMKHMSQ NQAVKRGYNS VMNESERFYR KRRQHSHSYS
   781  SDESLNRQNH LPEEFLRPPS TSVAPCKPKK KRRRKRGRFH PGFETLELKE NTDYPVKDNS
   841  SLNPLDRLIS EDKKEKMKPQ EVAKIERNSE QTNQLRNKLS FHPNNLLPSE TNGETEHLEM
   901  ETTSGELSDV SNDPTTSVCV ASAPTKEAID NTLLEHKERS ENINLNEKQI PFQVPNIERN
   961  FRQSQPKSYL CHYELAEALP QGKMNETPTE WLRYNSGILN TQPPLPFKEA HVSGHTFVTA
  1021  EQILAPLALP EQALLIPLEN HDKFKNVPCE VYQHILQPNM LANKVKFTFP PAALPPPSTP
  1081  LQPLPLQQSL CSTSVTTIHH TVLQQHAAAA AAAAAAAAAG TFKVLQPHQQ FLSQIPALTR
  1141  TSLPQLSVGP VGPRLCPGNQ PTFVAPPQMP IIPASVLHPS HLAFPSLPHA LFPSLLSPHP
  1201  TVIPLQPLF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF804A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.67
Highest tissue expression: 3.5 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 3.5 nTPM
retina: 3.5 nTPM
cerebral cortex: 3.4 nTPM
hypothalamus: 3.1 nTPM
basal ganglia: 2.8 nTPM
hippocampal formation: 2.1 nTPM

Single-cell type

podocytes: 833 nCPM
megakaryocyte-erythroid progenitors: 584 nCPM
brain inhibitory neurons: 495 nCPM
retinal bipolar cells: 470 nCPM
other brain neurons: 466 nCPM
retinal amacrine cells: 428 nCPM

Immune cell

intermediate monocyte: 0.3 nTPM
memory B-cell: 0.3 nTPM
classical monocyte: 0.2 nTPM
myeloid DC: 0.2 nTPM
neutrophil: 0.1 nTPM
non-classical monocyte: 0.1 nTPM

Brain region

cerebral cortex: 15 nTPM
cerebellum: 14 nTPM
hypothalamus: 12 nTPM
hippocampal formation: 11 nTPM
medulla oblongata: 8.1 nTPM
basal ganglia: 7.3 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ZNF804A.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 200 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Schizophrenia

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.48
gnomAD pLI: 0.01
gnomAD missense Z: -0.45
DepMap mean gene effect: 0.08
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

zinc ion binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF804A as an antibody target. Whether an autoantibody or antibody against ZNF804A could matter depends on whether native ZNF804A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF804A is annotated at the cell surface, where native ZNF804A is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label ZNF804A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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