Seroatlas · Human Serome Atlas

ZNF800

Zinc finger protein 800

Also known as: ZN800_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q2TB10
Gene: ZNF800
Ensembl: ENSG00000048405
Chromosome: 7
Canonical length: 664 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoli,Nucleoli rim,Cytosol

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to act upstream of or within acinar cell differentiation and endocrine pancreas development. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

664 residues, UniProt reviewed canonical sequence.

>Q2TB10|ZNF800
     1  MPLRDKYCQT DHHHHGCCEP VYILEPGDPP LLQQPLQTSK SGIQQIIECF RSGTKQLKHI
    61  LLKDVDTIFE CKLCRSLFRG LPNLITHKKF YCPPSLQMDD NLPDVNDKQS QAINDLLEAI
   121  YPSVDKREYI IKLEPIETNQ NAVFQYISRT DNPIEVTESS STPEQTEVQI QETSTEQSKT
   181  VPVTDTEVET VEPPPVEIVT DEVAPTSDEQ PQESQADLET SDNSDFGHQL ICCLCRKEFN
   241  SRRGVRRHIR KVHKKKMEEL KKYIETRKNP NQSSKGRSKN VLVPLSRSCP VCCKSFATKA
   301  NVRRHFDEVH RGLRRDSITP DIATKPGQPL FLDSISPKKS FKTRKQKSSS KAEYNLTACK
   361  CLLCKRKYSS QIMLKRHMQI VHKITLSGTN SKREKGPNNT ANSSEIKVKV EPADSVESSP
   421  PSITHSPQNE LKGTNHSNEK KNTPAAQKNK VKQDSESPKS TSPSAAGGQQ KTRKPKLSAG
   481  FDFKQLYCKL CKRQFTSKQN LTKHIELHTD GNNIYVKFYK CPLCTYETRR KRDVIRHITV
   541  VHKKSSRYLG KITASLEIRA IKKPIDFVLN KVAKRGPSRD EAKHSDSKHD GTSNSPSKKY
   601  EVADVGIEVK VTKNFSLHRC NKCGKAFAKK TYLEHHKKTH KANASNSPEG NKTKGRSTRS
   661  KALV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF800 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.54
Highest tissue expression: 70 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 70 nTPM
testis: 19 nTPM
lymph node: 16 nTPM
liver: 14 nTPM
tonsil: 13 nTPM
spleen: 13 nTPM

Single-cell type

neutrophil progenitors: 193 nCPM
esophageal apical cells: 126 nCPM
neutrophils: 116 nCPM
nk-cells: 106 nCPM
erythrocyte progenitors: 106 nCPM
early primary spermatocytes: 105 nCPM

Immune cell

NK-cell: 22 nTPM
basophil: 20 nTPM
naive CD8 T-cell: 19 nTPM
naive CD4 T-cell: 18 nTPM
T-reg: 17 nTPM
naive B-cell: 15 nTPM

Brain region

cerebellum: 57 nTPM
white matter: 31 nTPM
cerebral cortex: 30 nTPM
basal ganglia: 29 nTPM
thalamus: 29 nTPM
spinal cord: 28 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.16
gnomAD pLI: 1
gnomAD missense Z: 0.99
DepMap mean gene effect: 0.07
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

Zinc finger C2H2-type
Zinc finger C2H2 superfamily
Zinc-finger C2H2-type 11
ZFPM2-like, C-terminal CCHC zinc finger
Zinc finger, C2H2 type
zinc-finger C2H2-type
ZFPM2-like CCHC zinc finger
Zinc finger protein 800
Unstructured region upstream of a zinc-finger

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF800 as an antibody target. Whether an autoantibody or antibody against ZNF800 could matter depends on whether native ZNF800 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF800 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF800 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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