ZNF80
Zinc finger protein 80
Also known as: pT17, ZNF80_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- P51504
- Gene
- ZNF80
- Ensembl
- ENSG00000174255
- Chromosome
- 3
- Canonical length
- 273 aa
- Protein class
- Predicted intracellular proteins, Transcription factors
- Subcellular location
- Nucleoplasm,Nucleoli
OverviewNCBI Gene
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within negative regulation of transcription by RNA polymerase II. Predicted to be located in cytoplasm. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
273 residues, UniProt reviewed canonical sequence.
>P51504|ZNF80
1 MSPKRDGLGT GDGLHSQVLQ EQVSTGDNLH ECDSQGPSKD TLVREGKTYK CKECGSVFNK
61 NSLLVRHQQI HTGVKPYECQ ECGKAFPEKV DFVRPMRIHT GEKPCKCVEC GKVFNRRSHL
121 LCYRQIHTGE KPYECSECGK TFSYHSVFIQ HRVTHTGEKL FGCKECGKTF YYNSSLTRHM
181 KIHTGEKPCK CSECGKTFTY RSVFFRHSMT HTAGKPYECK ECGKGFYYSY SLTRHTRSHT
241 GEKPYECLEH RKDFGYHSAF AQQSKIHSGG KNLLocalizationUniProt · AlphaFold · HPA
Whether an antibody against ZNF80 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.43
- Highest tissue expression
- 2.9 nTPM
Expression across tissuesHPA
Tissue
- lymph node: 2.9 nTPM
- spleen: 1.2 nTPM
- appendix: 1 nTPM
- small intestine: 0.5 nTPM
- salivary gland: 0.4 nTPM
- gallbladder: 0.3 nTPM
Single-cell type
- t-cells: 9.6 nCPM
- nk-cells: 3.3 nCPM
- platelets: 2.8 nCPM
- early primary spermatocytes: 0.8 nCPM
- undifferentiated spermatogonia: 0.8 nCPM
- b-cells: 0.5 nCPM
Immune cell
- T-reg: 1.2 nTPM
- memory CD8 T-cell: 0.7 nTPM
- naive B-cell: 0.3 nTPM
- gdT-cell: 0.2 nTPM
- memory CD4 T-cell: 0.2 nTPM
- naive CD4 T-cell: 0.2 nTPM
Brain region
- amygdala: 0.1 nTPM
- basal ganglia: 0.1 nTPM
- cerebral cortex: 0.1 nTPM
- hippocampal formation: 0.1 nTPM
- hypothalamus: 0.1 nTPM
- medulla oblongata: 0.1 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD missense Z
- -0.14
- DepMap mean gene effect
- -0.09
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
- DNA-binding transcription factor activity, RNA polymerase II-specific
- RNA polymerase II transcription regulatory region sequence-specific DNA binding
- zinc ion binding
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads ZNF80 as an antibody target. Whether an autoantibody or antibody against ZNF80 could matter depends on whether native ZNF80 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
ZNF80 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label ZNF80 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
Loading the interactive Seroatlas protein explorer...