ZNF8

Protein identityUniProt · HPA

UniProt accession

P17098

Gene

ZNF8

Ensembl

ENSG00000278129

Chromosome

19

Canonical length

575 aa

Protein class

Predicted intracellular proteins, Transcription factors

Subcellular location

Nucleoplasm,Nuclear bodies

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to act upstream of or within BMP signaling pathway. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

575 residues, UniProt reviewed canonical sequence.

>P17098|ZNF8
     1  MDPEDEGVAG VMSVGPPAAR LQEPVTFRDV AVDFTQEEWG QLDPTQRILY RDVMLETFGH
    61  LLSIGPELPK PEVISQLEQG TELWVAERGT TQGCHPAWEP RSESQASRKE EGLPEEEPSH
   121  VTGREGFPTD APYPTTLGKD RECQSQSLAL KEQNNLKQLE FGLKEAPVQD QGYKTLRLRE
   181  NCVLSSSPNP FPEISRGEYL YTYDSQITDS EHNSSLVSQQ TGSPGKQPGE NSDCHRDSSQ
   241  AIPITELTKS QVQDKPYKCT DCGKSFNHNA HLTVHKRIHT GERPYMCKEC GKAFSQNSSL
   301  VQHERIHTGD KPYKCAECGK SFCHSTHLTV HRRIHTGEKP YECQDCGRAF NQNSSLGRHK
   361  RTHTGEKPYT CSVCGKSFSR TTCLFLHLRT HTEERPYECN HCGKGFRHSS SLAQHQRKHA
   421  GEKPFECRQR LIFEQTPALT KHEWTEALGC DPPLSQDERT HRSDRPFKCN QCGKCFIQSS
   481  HLIRHQITHT REEQPHGRSR RREQSSSRNS HLVQHQHPNS RKSSAGGAKA GQPESRALAL
   541  FDIQKIMQEK NPVHVIGVEE PSVGASMLFD IREST

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF8 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.55

Highest tissue expression

3.6 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.69

gnomAD pLI

0.02

gnomAD missense Z

1.38

DepMap mean gene effect

0.01

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• BMP signaling pathway
• negative regulation of transcription by RNA polymerase II

Molecular functions

• DNA binding
• DNA-binding transcription factor activity, RNA polymerase II-specific
• RNA polymerase II cis-regulatory region sequence-specific DNA binding
• zinc ion binding

Cellular components

• nucleus

Protein domainsUniProt · Pfam · InterPro

• Krueppel-associated box
• Zinc finger C2H2-type
• Krueppel-associated box domain superfamily
• Zinc finger C2H2 superfamily
• Zinc finger, C2H2 type
• KRAB box

KeywordsUniProt

• DNA-binding
• Isopeptide bond
• Metal-binding
• Nucleus
• Repeat
• Transcription
• Transcription regulation
• Ubl conjugation
• Zinc
• Zinc-finger

InteractionsUniProt · HPA

Protein binding partners of ZNF8 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• SMAD1
• SMAD5
• TRIM28