Seroatlas · Human Serome Atlas

ZNF799

Zinc finger protein 799

Also known as: HIT-40, MGC71805, ZN799_HUMAN, ZNF842

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96GE5
Gene
ZNF799
Ensembl
ENSG00000196466
Chromosome
19
Canonical length
643 aa
Protein class
Predicted intracellular proteins, Transcription factors
Subcellular location
Nucleoplasm,Centriolar satellite

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

643 residues, UniProt reviewed canonical sequence.

>Q96GE5|ZNF799
     1  MASVALEDVA VNFTREEWAL LGPCQKNLYK DVMQETIRNL DCVGMKWKDQ NIEDQYRYPR
    61  KNLRCRMLER FVESKDGTQC GETSSQIQDS IVTKNTLPGV GPYESRMSGE VIMGHSSLNC
   121  YIRVGAGHKP YEYHECGEKP DTHKQRGKAF SYHNSLQTHE RLHTGKKPYN CKECGKSFSS
   181  LGNLQRHMAV QRGDGPYKCK LCGKAFFWPS LLHMHERTHT GEKPYECKQC SKAFSFYSSY
   241  LRHERTHTGE KLYECKQCSK AFPDYSSCLR HERTHTGKKP YTCKQCGKAF SASTSLRRHE
   301  TTHTDEKPYA CQQCGKAFHH LGSFQRHMVM HTRDGPHKCK ICGKGFDCPS SLKSHERTHT
   361  GEKLYECKQC GKALSHSSSF RRHMTMHTGD GPHKCKICGK AFVYPSVFQR HEKTHTAEKP
   421  YKCKQCGKAY RISSSLRRHE TTHTGEKPYK CKCGKAFIDF YSFQNHKTTH AGEKPYECKE
   481  CGKAFSCFQY LSQHRRTHTG EKPYECNTCK KAFSHFGNLK VHERIHSGEK PYECKECGKA
   541  FSWLTCFLRH ERIHMREKPY ECQQCGKAFT HSRFLQGHEK THTGENPYEC KECGKAFASL
   601  SSLHRHKKTH WKKTHTGENP YGCKECGKAF ASLSSLHRHK KTH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF799 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.44
Highest tissue expression
4.5 nTPM

Expression across tissuesHPA

Tissue

  • placenta: 4.5 nTPM
  • fallopian tube: 3.7 nTPM
  • ovary: 3.6 nTPM
  • breast: 3.5 nTPM
  • liver: 3.5 nTPM
  • cervix: 3.2 nTPM

Single-cell type

  • thymocytes: 0.8 nCPM
  • megakaryocyte progenitors: 0.5 nCPM
  • pericytes: 0.4 nCPM
  • basal prostatic cells: 0.3 nCPM
  • fallopian tube ciliated cells: 0.3 nCPM
  • breast lactating cells: 0.2 nCPM

Immune cell

  • memory CD8 T-cell: 5.7 nTPM
  • memory B-cell: 4.7 nTPM
  • MAIT T-cell: 4.5 nTPM
  • T-reg: 4.5 nTPM
  • naive B-cell: 4.4 nTPM
  • gdT-cell: 3.9 nTPM

Brain region

  • cerebellum: 7.6 nTPM
  • thalamus: 5.9 nTPM
  • medulla oblongata: 5.8 nTPM
  • white matter: 5.8 nTPM
  • hippocampal formation: 5.4 nTPM
  • midbrain: 5.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.57
gnomAD pLI
0.02
gnomAD missense Z
-1.14
DepMap mean gene effect
0.06
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF799 as an antibody target. Whether an autoantibody or antibody against ZNF799 could matter depends on whether native ZNF799 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF799 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF799 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ZNF799. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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