Seroatlas · Human Serome Atlas

ZNF793

Zinc finger protein 793

Also known as: ZN793_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6ZN11
Gene: ZNF793
Ensembl: ENSG00000188227
Chromosome: 19
Canonical length: 406 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Nucleoli,Cytosol

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Implicated in Barrett's esophagus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

406 residues, UniProt reviewed canonical sequence.

>Q6ZN11|ZNF793
     1  MIEYQIPVSF KDVVVGFTQE EWHRLSPAQR ALYRDVMLET YSNLVSVGYE GTKPDVILRL
    61  EQEEAPWIGE AACPGCHCWE DIWRVNIQRK RRQDMLLRPG AAISKKTLPK EKSCEYNKFG
   121  KISLLSTDLF SSIQSPSNWN PCGKNLNHNL DLIGFKRNCA KKQDECYAYG KLLQRINHGR
   181  RPNGEKPRGC SHCEKAFTQN PALMYKPAVS DSLLYKRKRV PPTEKPHVCS ECGKAFCYKS
   241  EFIRHQRSHT GEKPYGCTDC GKAFSHKSTL IKHQRIHTGV RPFECFFCGK AFTQKSHRTE
   301  HQRTHTGERP FVCSECGKSF GEKSYLNVHR KMHTGERPYR CRECGKSFSQ KSCLNKHWRT
   361  HTGEKPYGCN ECGKAFYQKP NLSRHQKIHA RKNAYRNENL IIVGNT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF793 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.48
Highest tissue expression: 14 nTPM

Expression across tissuesHPA

Tissue

retina: 14 nTPM
cerebellum: 13 nTPM
pituitary gland: 8.5 nTPM
testis: 8.4 nTPM
ovary: 7.6 nTPM
basal ganglia: 6.1 nTPM

Single-cell type

sertoli cells: 76 nCPM
thyrotrophs: 59 nCPM
lactotrophs: 53 nCPM
early spermatids: 50 nCPM
oligodendrocyte progenitor cells: 49 nCPM
somatotrophs: 48 nCPM

Immune cell

basophil: 4 nTPM
NK-cell: 1.6 nTPM
neutrophil: 1.5 nTPM
naive B-cell: 1.4 nTPM
memory CD4 T-cell: 1.1 nTPM
memory CD8 T-cell: 1 nTPM

Brain region

cerebellum: 30 nTPM
amygdala: 22 nTPM
basal ganglia: 22 nTPM
cerebral cortex: 22 nTPM
white matter: 21 nTPM
hypothalamus: 21 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.29
gnomAD pLI: 0
gnomAD missense Z: 0.1
DepMap mean gene effect: -0.05
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of transcription by RNA polymerase II

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF793 as an antibody target. Whether an autoantibody or antibody against ZNF793 could matter depends on whether native ZNF793 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF793 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF793 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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