ZNF791

Protein identityUniProt · HPA

UniProt accession

Q3KP31

Gene

ZNF791

Ensembl

ENSG00000173875

Chromosome

19

Canonical length

576 aa

Protein class

Predicted intracellular proteins, Transcription factors

Subcellular location

Nucleoplasm

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

576 residues, UniProt reviewed canonical sequence.

>Q3KP31|ZNF791
     1  MDSVAFEDVS VSFSQEEWAL LAPSQKKLYR DVMQETFKNL ASIGEKWEDP NVEDQHKNQG
    61  RNLRSHTGER LCEGKEGSQC AENFSPNLSV TKKTAGVKPY ECTICGKAFM RLSSLTRHMR
   121  SHTGYELFEK PYKCKECEKA FSYLKSFQRH ERSHTGEKPY KCKQCGKTFI YHQPFQRHER
   181  THIGEKPYEC KQCGKALSCS SSLRVHERIH TGEKPYECKQ CGKAFSCSSS IRVHERTHTG
   241  EKPYACKECG KAFISHTSVL THMITHNGDR PYKCKECGKA FIFPSFLRVH ERIHTGEKPY
   301  KCKQCGKAFR CSTSIQIHER IHTGEKPYKC KECGKSFSAR PAFRVHVRVH TGEKPYKCKE
   361  CGKAFSRISY FRIHERTHTG EKPYECKKCG KTFNYPLDLK IHKRNHTGEK PYECKECAKT
   421  FISLENFRRH MITHTGDGPY KCRDCGKVFI FPSALRTHER THTGEKPYEC KQCGKAFSCS
   481  SYIRIHKRTH TGEKPYECKE CGKAFIYPTS FQGHMRMHTG EKPYKCKECG KAFSLHSSFQ
   541  RHTRIHNYEK PLECKQCGKA FSVSTSLKKH MRMHNR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF791 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.42

Highest tissue expression

13 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.52

gnomAD pLI

0.13

gnomAD missense Z

1.52

DepMap mean gene effect

-0.05

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• regulation of transcription by RNA polymerase II

Molecular functions

• DNA-binding transcription factor activity, RNA polymerase II-specific
• RNA polymerase II transcription regulatory region sequence-specific DNA binding
• zinc ion binding

Cellular components

• nucleus

Protein domainsUniProt · Pfam · InterPro

• Krueppel-associated box
• Zinc finger C2H2-type
• Krueppel-associated box domain superfamily
• Zinc finger C2H2 superfamily
• Ikaros C2H2-type zinc-finger
• Zinc finger, C2H2 type
• KRAB box

KeywordsUniProt

• DNA-binding
• Metal-binding
• Nucleus
• Repeat
• Transcription
• Transcription regulation
• Zinc
• Zinc-finger

InteractionsUniProt · HPA

Protein binding partners of ZNF791 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• TRIM28