Seroatlas · Human Serome Atlas

ZNF790

Zinc finger protein 790

Also known as: FLJ20350, MGC62100, ZN790_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6PG37
Gene: ZNF790
Ensembl: ENSG00000197863
Chromosome: 19
Canonical length: 636 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoli

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

636 residues, UniProt reviewed canonical sequence.

>Q6PG37|ZNF790
     1  MAHLMMFRDV AVDFSQEEWE CLDLEQRDLY RDVMLENYSN MVSLGFCIYQ PEAFSLLEKG
    61  KEPWKILRDE TRGPCPDMQS RCQTKKLLPK NGIFEREIAQ LEIMRICKNH SLDCLCFRGD
   121  WEGNTQFQTL QDNQEECFKQ VIRTCEKRPT FNQHTVFNLH QRLNTGDKLN EFKELGKAFI
   181  SGSDHTQHQL IHTSEKFCGD KECGNTFLPD SEVIQYQTVH TVKKTYECKE CGKSFSLRSS
   241  LTGHKRIHTG EKPFKCKDCG KAFRFHSQLS VHKRIHTGEK SYECKECGKA FSCGSDLTRH
   301  QRIHTGEKPY ECNECRKAFS QRSHLIKHQR IHTGEKPYEC KECGKAFTRG SHLTQHQRIH
   361  TGEKSHECKE CGKAFIRGSN LAQHQNVHVG RKPYKCEKCG KAYIWSSHLA RHQRIHTGRK
   421  PYECKQCGKT FTWASYLAQH EKIHNERKSY ECKECGKTFL HGSEFNRHQK IHTGERNYEC
   481  KECGKTFFRG SELNRHQKIH TGKRPYECEE CGKAFLWGSQ LTRHQRMHTG EEPYVCKECG
   541  KSFIWGSQLT RHKKIHTDAE PYGCKKSSHI FSHHSYFTEQ KIHNSANLCE WTDYGNTFSH
   601  ESNFAQHQNI YTFEKSYEFK DFEKAFSSSS HFISLL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF790 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.46
Highest tissue expression: 10 nTPM

Expression across tissuesHPA

Tissue

testis: 10 nTPM
skin: 8.9 nTPM
liver: 8.2 nTPM
thyroid gland: 7.5 nTPM
retina: 7.4 nTPM
kidney: 5.5 nTPM

Single-cell type

early spermatids: 185 nCPM
cardiomyocytes: 100 nCPM
retinal bipolar cells: 58 nCPM
rod photoreceptor cells: 48 nCPM
late spermatids: 47 nCPM
fibro-adipogenic progenitors: 46 nCPM

Immune cell

naive B-cell: 7.8 nTPM
memory B-cell: 6.8 nTPM
naive CD4 T-cell: 5.8 nTPM
memory CD4 T-cell: 5.6 nTPM
memory CD8 T-cell: 5.6 nTPM
eosinophil: 5.1 nTPM

Brain region

cerebellum: 31 nTPM
medulla oblongata: 25 nTPM
hypothalamus: 24 nTPM
white matter: 24 nTPM
midbrain: 22 nTPM
basal ganglia: 22 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.33
gnomAD pLI: 0
gnomAD missense Z: -0.17
DepMap mean gene effect: 0.16
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of transcription by RNA polymerase II

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF790 as an antibody target. Whether an autoantibody or antibody against ZNF790 could matter depends on whether native ZNF790 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF790 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF790 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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