Seroatlas · Human Serome Atlas

ZNF79

Zinc finger protein 79

Also known as: pT7, ZNF79_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q15937
Gene
ZNF79
Ensembl
ENSG00000196152
Chromosome
9
Canonical length
498 aa
Protein class
Predicted intracellular proteins, Transcription factors
Subcellular location
Nucleoplasm,Plasma membrane,Cytosol

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

498 residues, UniProt reviewed canonical sequence.

>Q15937|ZNF79
     1  MLEEGVLPSP GPALPQEENT GEEGMAAGLL TAGPRGSTFF SSVTVAFAQE RWRCLVSTPR
    61  DRFKEGIPGK SRSLVLLGLP VSQPGMNSQL EQREGAWMLE GEDLRSPSPG WKIISGSPPE
   121  QALSEASFQD PCVEMPPGDS DHGTSDLEKS FNLRPVLSPQ QRVPVEARPR KCETHTESFK
   181  NSEILKPHRA KPYACNECGK AFSYCSSLSQ HQKSHTGEKP YECSECGKAF SQSSSLIQHQ
   241  RIHTGEKPYK CSECGRAFSQ NANLTKHQRT HTGEKPYRCS ECEKAFSDCS ALVQHQRIHT
   301  GEKPYECSDC GKAFRHSANL TNHQRTHTGE KPYKCSECGK AFSYCAAFIQ HQRIHTGEKP
   361  YRCAACGKAF SQSANLTNHQ RTHTGEKPYK CSECGKAFSQ STNLIIHQKT HTGEKPYKCN
   421  ECGKFFSESS ALIRHHIIHT GEKPYECNEC GKAFNQSSSL SQHQRIHTGV KPYECSECGK
   481  AFRCSSAFVR HQRLHAGE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF79 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.48
Highest tissue expression
5.8 nTPM

Expression across tissuesHPA

Tissue

  • testis: 5.8 nTPM
  • thymus: 5.1 nTPM
  • urinary bladder: 5 nTPM
  • tongue: 4.9 nTPM
  • parathyroid gland: 4.6 nTPM
  • skeletal muscle: 4.5 nTPM

Single-cell type

  • endometrial stromal cells: 23 nCPM
  • cardiomyocytes: 20 nCPM
  • medullary thymic epithelial cells: 19 nCPM
  • myonuclei: 14 nCPM
  • late primary spermatocytes: 13 nCPM
  • choroid plexus epithelial cells: 12 nCPM

Immune cell

  • memory CD8 T-cell: 7.6 nTPM
  • NK-cell: 7.2 nTPM
  • MAIT T-cell: 6.7 nTPM
  • gdT-cell: 6 nTPM
  • naive B-cell: 5.8 nTPM
  • naive CD8 T-cell: 5.8 nTPM

Brain region

  • cerebellum: 16 nTPM
  • medulla oblongata: 10 nTPM
  • white matter: 9.8 nTPM
  • basal ganglia: 9.6 nTPM
  • choroid plexus: 9.6 nTPM
  • hypothalamus: 9.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.69
gnomAD pLI
0.01
gnomAD missense Z
0.21
DepMap mean gene effect
-0.07
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF79 as an antibody target. Whether an autoantibody or antibody against ZNF79 could matter depends on whether native ZNF79 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF79 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF79 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ZNF79. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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