Seroatlas · Human Serome Atlas

ZNF787

Zinc finger protein 787

Also known as: ZN787_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6DD87
Gene: ZNF787
Ensembl: ENSG00000142409
Chromosome: 19
Canonical length: 382 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli,Mitochondria

OverviewNCBI Gene

Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

382 residues, UniProt reviewed canonical sequence.

>Q6DD87|ZNF787
     1  MELREEAWSP GPLDSEDQQM ASHENPVDIL IMDDDDVPSW PPTKLSPPQS APPAGPPPRP
    61  RPPAPYICNE CGKSFSHWSK LTRHQRTHTG ERPNACADCG KTFSQSSHLV QHRRIHTGEK
   121  PYACLECGKR FSWSSNLMQH QRIHTGEKPY TCPDCGRSFT QSKSLAKHRR SHSGLKPFVC
   181  PRCGRGFSQP KSLARHLRLH PELSGPGVAA KVLAASVRRA KGPEEAVAAD GEIAIPVGDG
   241  EGIIVVGAPG EGAAAAAAMA GAGAKAAGPR SRRAPAPKPY VCLECGKGFG HGAGLLAHQR
   301  AQHGDGLGAA GGEEPAHICV ECGEGFVQGA ALRRHKKIHA VGAPSVCSSC GQSYYRAGGE
   361  EEDDDDEAAG GRCPECRGGE GR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF787 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.51
Highest tissue expression: 42 nTPM

Expression across tissuesHPA

Tissue

liver: 42 nTPM
skeletal muscle: 40 nTPM
pancreas: 33 nTPM
spleen: 26 nTPM
bone marrow: 25 nTPM
heart muscle: 25 nTPM

Single-cell type

cone photoreceptor cells: 133 nCPM
endometrial ciliated cells: 105 nCPM
neutrophils: 92 nCPM
endometrial luminal cells: 72 nCPM
neutrophil progenitors: 64 nCPM
fallopian secretory cells: 62 nCPM

Immune cell

plasmacytoid DC: 2.2 nTPM
neutrophil: 1.8 nTPM
naive B-cell: 1.4 nTPM
eosinophil: 1.1 nTPM
memory B-cell: 1 nTPM
classical monocyte: 0.8 nTPM

Brain region

thalamus: 31 nTPM
medulla oblongata: 30 nTPM
cerebral cortex: 28 nTPM
basal ganglia: 26 nTPM
white matter: 26 nTPM
amygdala: 26 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.42
gnomAD pLI: 0.89
gnomAD missense Z: 2.44
DepMap mean gene effect: 0.04
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of transcription by RNA polymerase II

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF787 as an antibody target. Whether an autoantibody or antibody against ZNF787 could matter depends on whether native ZNF787 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF787 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF787 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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