Seroatlas · Human Serome Atlas

ZNF784

Zinc finger protein 784

Also known as: MGC75238, ZN784_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NCA9
Gene: ZNF784
Ensembl: ENSG00000179922
Chromosome: 19
Canonical length: 323 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within hematopoietic progenitor cell differentiation. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

323 residues, UniProt reviewed canonical sequence.

>Q8NCA9|ZNF784
     1  MAAARPEAQS RSSPTPESRS QEPLDLVLVP DDCRPGTPPS DLIEIQVVKV TDTTLVPEPP
    61  EPGSFHCALC PAAFRLVSEL LFHEHGHLAG AEGGGQGGDP SRCHVCGHSC PGPASLRAHY
   121  SLHTGERPYR CALCPRAFKA LAPLLRHQHR HGVEPGTSRR PPDTAAVAEQ RPGVAPERAE
   181  VVMAAAAAGA AVGKPFACRF CAKPFRRSSD MRDHERVHTG ERPYHCGICG KGFTQSSVLS
   241  GHARIHTGER PFRCTLCDRT FNNSSNFRKH QRTHFHGPGP GLGDSGGQLG SSAAEGSGSG
   301  CGVGDPAEEG RGETAKVKVE ADQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF784 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.54
Highest tissue expression: 40 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 40 nTPM
tongue: 15 nTPM
heart muscle: 13 nTPM
colon: 12 nTPM
liver: 12 nTPM
ovary: 12 nTPM

Single-cell type

myonuclei: 21 nCPM
syncytiotrophoblasts: 12 nCPM
thymic myoid cells: 12 nCPM
enterocytes: 12 nCPM
colonocytes: 10 nCPM
granulosa cells: 9.7 nCPM

Immune cell

eosinophil: 0.6 nTPM
classical monocyte: 0.4 nTPM
intermediate monocyte: 0.4 nTPM
myeloid DC: 0.3 nTPM
NK-cell: 0.3 nTPM
non-classical monocyte: 0.3 nTPM

Brain region

cerebellum: 10 nTPM
medulla oblongata: 8.9 nTPM
white matter: 8.8 nTPM
cerebral cortex: 8.4 nTPM
amygdala: 7.7 nTPM
thalamus: 7.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.52
gnomAD pLI: 0.83
gnomAD missense Z: 0.74
DepMap mean gene effect: -0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF784 as an antibody target. Whether an autoantibody or antibody against ZNF784 could matter depends on whether native ZNF784 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF784 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF784 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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