Seroatlas · Human Serome Atlas

ZNF782

Zinc finger protein 782

Also known as: FLJ16636, ZN782_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6ZMW2
Gene: ZNF782
Ensembl: ENSG00000196597
Chromosome: 9
Canonical length: 699 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Mitochondria

OverviewNCBI Gene

Predicted to enable DNA binding activity and zinc ion binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

699 residues, UniProt reviewed canonical sequence.

>Q6ZMW2|ZNF782
     1  MNTFQASVSF QDVTVEFSQE EWQHMGPVER TLYRDVMLEN YSHLVSVGYC FTKPELIFTL
    61  EQGEDPWLLE KEKGFLSRNS PEDSQPDEIS EKSPENQGKH LLQVLFTNKL LTTEQEISGK
   121  PHNRDINIFR ARMMPCKCDI AGSACQGLSL MAPHCQYSKE KAHERNVCDK WLISIKDGRT
   181  NTQEKSFAYS KIVKTLHHKE EVIQHQTIQT LGQDFEYNES RKAFLEKAAL VTSNSTHPKG
   241  KSYNFNKFGE NKYDKSTFII PQNMNPEKSH YEFNDTGNCF CRITHKTLTG GKSFSQKSHI
   301  REHHRVHIGV KPFEYGKSFN RNSTLPVHQR THATDKYSDY HPCTETFSYQ STFSVHQKVH
   361  IRAKPYEYNE CGKSCSMNSH LIWPQKSHTG EKPYECPECG KAFSEKSRLR KHQRTHTGEK
   421  PYKCDGCDKA FSAKSGLRIH QRTHTGEKPF ECHECGKSFN YKSILIVHQR THTGEKPFEC
   481  NECGKSFSHM SGLRNHRRTH TGERPYKCDE CGKAFKLKSG LRKHHRTHTG EKPYKCNQCG
   541  KAFGQKSQLR GHHRIHTGEK PYKCNHCGEA FSQKSNLRVH HRTHTGEKPY QCEECGKTFR
   601  QKSNLRGHQR THTGEKPYEC NECGKAFSEK SVLRKHQRTH TGEKPYNCNQ CGEAFSQKSN
   661  LRVHQRTHTG EKPYKCDKCG RTFSQKSSLR EHQKAHPGD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF782 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.52
Highest tissue expression: 8.6 nTPM

Expression across tissuesHPA

Tissue

retina: 8.6 nTPM
testis: 5.8 nTPM
pancreas: 4.5 nTPM
skin: 3.8 nTPM
epididymis: 3.7 nTPM
thyroid gland: 3.2 nTPM

Single-cell type

myonuclei: 105 nCPM
oligodendrocytes: 78 nCPM
corticotrophs: 77 nCPM
oligodendrocyte progenitor cells: 74 nCPM
somatotrophs: 74 nCPM
adrenal cortex cells: 70 nCPM

Immune cell

MAIT T-cell: 0.5 nTPM
naive B-cell: 0.4 nTPM
gdT-cell: 0.3 nTPM
classical monocyte: 0.2 nTPM
memory CD4 T-cell: 0.2 nTPM
memory CD8 T-cell: 0.2 nTPM

Brain region

cerebellum: 37 nTPM
white matter: 25 nTPM
cerebral cortex: 24 nTPM
amygdala: 22 nTPM
thalamus: 22 nTPM
hippocampal formation: 21 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.08
gnomAD pLI: 0
gnomAD missense Z: 0.25
DepMap mean gene effect: -0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of transcription by RNA polymerase II

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF782 as an antibody target. Whether an autoantibody or antibody against ZNF782 could matter depends on whether native ZNF782 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF782 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF782 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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