Seroatlas · Human Serome Atlas

ZNF781

Zinc finger protein 781

Also known as: ZN781_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N8C0
Gene: ZNF781
Canonical length: 355 aa

OverviewNCBI Gene

No narrative summary is available for ZNF781 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

355 residues, UniProt reviewed canonical sequence.

>Q8N8C0|ZNF781
     1  MQRNAMYLKN VAETACNFQL TQYQISHANQ KPYECQICGK PFRKRAHLTQ HNRIHTGGKP
    61  YECKECGKVF ICCSTLIQHK RTHTSEKPYE CLECRKTFRR SAHLIRHQRI HTGEKPYKCK
   121  QCWKAFASVS DLIDIGKFTL MRDFTNVQNV GRHLTIAQLL FSIREFTLVR SPLNVRNVAK
   181  HSIIAQHLLN TRELILMRNL MNVRNVKRLL GKVHILLNIK EFILVRNHMS VSNVGRLSLV
   241  FLILIDIREF TLVKNPMNVK NVVELLTIVQ LLFNTREFTL VRRLMNISSV GRFLSPVQHL
   301  FNIREHILMK NLMNVSNARR PSSIMHILFD IKEFILVRNL INVSNVGRPL LLFLI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF781 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.31

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD missense Z: 0.49

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF781 as an antibody target. Whether an autoantibody or antibody against ZNF781 could matter depends on whether native ZNF781 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF781 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF781 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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