Seroatlas · Human Serome Atlas

ZNF775

Zinc finger protein 775

Also known as: MGC33584, ZN775_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96BV0
Gene: ZNF775
Ensembl: ENSG00000196456
Chromosome: 7
Canonical length: 537 aa
Protein class: Predicted intracellular proteins, Transcription factors

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

537 residues, UniProt reviewed canonical sequence.

>Q96BV0|ZNF775
     1  MESGLAGNGT GAGLVMKVKQ EKPERLLQTL APQAMLVEKD KENIFQQHRG LPPRQTMGRP
    61  RALGGQEESG SPRWAPPTEQ DAGLAGRAPG SASGPLSPSL SSGEGHFVCL DCGKRFSWWS
   121  SLKIHQRTHT GEKPYLCGKC GKSFSQKPNL ARHQRHHTGE RPFCCPECAR RFSQKQHLLK
   181  HQKTHSRPAT HSCPECERCF RHQVGLRIHQ RAHARDRQGS RAGLHELIQD AAARRACRLQ
   241  PGPPRGRPEW AWLGLCQGWW GQPGARAAVS GPEGPGEPRQ FICNECGKSF TWWSSLNIHQ
   301  RIHTGERPYA CPECGRRFSQ KPNLTRHLRN HTGERPHPCP HCGRGFRQKQ HLLKHLRTHL
   361  PGAQAAPCPS CGKSCRSRAA LRAHQRAHAV AEPAVPAGEP GDQPQAEAIP GLAARPRSSQ
   421  RSPGARDTLW GRGQAGLAGP GEPRQFICNE CGKSFSWWSA LTIHQRIHTG ERPYPCPECG
   481  RRFSQKPNLT RHRRNHTGER PYLCPACGRG FSQKQHLLKH QRVHRAAPAC SPKEEAR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF775 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.53
Highest tissue expression: 12 nTPM

Expression across tissuesHPA

Tissue

spinal cord: 12 nTPM
basal ganglia: 11 nTPM
midbrain: 9.9 nTPM
hippocampal formation: 9.8 nTPM
colon: 9.7 nTPM
amygdala: 9.4 nTPM

Single-cell type

gonadotrophs: 7.4 nCPM
thyrotrophs: 6.2 nCPM
myonuclei: 6.1 nCPM
thymocytes: 5.9 nCPM
pdcs: 5.6 nCPM
lactotrophs: 5.3 nCPM

Immune cell

plasmacytoid DC: 0.4 nTPM
neutrophil: 0.3 nTPM
eosinophil: 0.2 nTPM
myeloid DC: 0.2 nTPM
classical monocyte: 0.1 nTPM
gdT-cell: 0.1 nTPM

Brain region

white matter: 28 nTPM
basal ganglia: 26 nTPM
medulla oblongata: 24 nTPM
cerebral cortex: 23 nTPM
thalamus: 23 nTPM
cerebellum: 22 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.83
gnomAD pLI: 0
gnomAD missense Z: 1.49
DepMap mean gene effect: 0.03
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of transcription by RNA polymerase II

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF775 as an antibody target. Whether an autoantibody or antibody against ZNF775 could matter depends on whether native ZNF775 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF775 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF775 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...