Seroatlas · Human Serome Atlas

ZNF773

Zinc finger protein 773

Also known as: MGC4728, ZN773_HUMAN, ZNF419B

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6PK81
Gene: ZNF773
Ensembl: ENSG00000152439
Chromosome: 19
Canonical length: 442 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Nucleoli fibrillar center

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

442 residues, UniProt reviewed canonical sequence.

>Q6PK81|ZNF773
     1  MAAATLRDPA QQGYVTFEDV AVYFSQEEWR LLDDAQRLLY RNVMLENFTL LASLGLASSK
    61  THEITQLESW EEPFMPAWEV VTSAILRGSW QGAKAEAAAE QSASVEVPSS NVQQHQKQHC
   121  GEKPLKRQEG RVPVLRSCRV HLSEKSLQSR EVGKDLLTSS GVLKHQVTHT GEKSHRSSKS
   181  REAFHAGKRH YKCSECGKAF GQKYLLVQHQ RLHTGEKPYE CSECGKLFSH KSNLFIHQIV
   241  HTGERPYGCS DCGKSFSRNA DLIQHQRVHT GEKPFTCSEC GKAFRHNSTL VQHHRIHTGV
   301  RPYECSECGK LFSFNSSLMK HQRVHTGERP YKCSECGKFY SHKSSLINHW RVHTGERPYE
   361  CSECGKFFSQ SSSLMQHRKV HTGEKPFKCN ECGRFFSENS SLVKHQRVHT GAKPYECREC
   421  GKFFRHSSSL VKHRRIHTGE IQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF773 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.47
Highest tissue expression: 6.5 nTPM

Expression across tissuesHPA

Tissue

parathyroid gland: 6.5 nTPM
bone marrow: 6.2 nTPM
thyroid gland: 5.7 nTPM
breast: 5.6 nTPM
spleen: 5.3 nTPM
tonsil: 5.2 nTPM

Single-cell type

brain excitatory neurons: 8.1 nCPM
bergmann glia: 7.7 nCPM
brain inhibitory neurons: 7.4 nCPM
choroid plexus epithelial cells: 7.2 nCPM
other brain neurons: 6.5 nCPM
astrocytes: 6 nCPM

Immune cell

basophil: 31 nTPM
naive CD4 T-cell: 22 nTPM
naive B-cell: 19 nTPM
MAIT T-cell: 18 nTPM
naive CD8 T-cell: 17 nTPM
memory B-cell: 15 nTPM

Brain region

cerebellum: 24 nTPM
cerebral cortex: 21 nTPM
hypothalamus: 21 nTPM
white matter: 21 nTPM
basal ganglia: 20 nTPM
amygdala: 20 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.45
gnomAD pLI: 0
gnomAD missense Z: -1.15
DepMap mean gene effect: 0.06
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of transcription by RNA polymerase II

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF773 as an antibody target. Whether an autoantibody or antibody against ZNF773 could matter depends on whether native ZNF773 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF773 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF773 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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