Seroatlas · Human Serome Atlas

ZNF772

Zinc finger protein 772

Also known as: DKFZp686I1569, ZN772_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q68DY9
Gene: ZNF772
Ensembl: ENSG00000197128
Chromosome: 19
Canonical length: 489 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Cytosol

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

489 residues, UniProt reviewed canonical sequence.

>Q68DY9|ZNF772
     1  MAAAEPMGPA QVPMNSEVIV DPIQGQVNFE DVFVYFSQEE WVLLDEAQRL LYRDVMLENF
    61  ALMASLGHTS FMSHIVASLV MGSEPWVPDW VDMTLAVATE TPGGSDPGCW HGMEDEEIPF
   121  EQSFSIGMSQ IRIPKGGPST QKAYPCGTCG LVLKDILHLA EHQETHPGQK PYMCVLCGKQ
   181  FCFSANLHQH QKQHSGEKPF RSDKSRPFLL NNCAVQSMEM SFVTGEACKD FLASSSIFEH
   241  HAPHNEWKPH SNTKCEEASH CGKRHYKCSE CGKTFSRKDS LVQHQRVHTG ERPYECGECG
   301  KTFSRKPILA QHQRIHTGEM PYECGICGKV FNHSSNLIVH QRVHTGARPY KCSECGKAYS
   361  HKSTLVQHES IHTGERPYEC SECGKYFGHK YRLIKHWSVH TGARPYECIA CGKFFSQSSD
   421  LIAHQRVHNG EKPYVCSECG KAFSHKHVLV QHHRIHTGER PYKCSECGKA FRQRASLIRH
   481  WKIHTGERP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF772 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.48
Highest tissue expression: 13 nTPM

Expression across tissuesHPA

Tissue

retina: 13 nTPM
parathyroid gland: 10 nTPM
thyroid gland: 8.5 nTPM
tongue: 7.3 nTPM
heart muscle: 6.5 nTPM
thymus: 5.6 nTPM

Single-cell type

hematopoietic stem cells: 1 nCPM
epididymal efferent duct ciliated cells: 0.8 nCPM
thyrotrophs: 0.8 nCPM
cardiomyocytes: 0.6 nCPM
lactotrophs: 0.6 nCPM
myonuclei: 0.5 nCPM

Immune cell

naive B-cell: 3.7 nTPM
memory B-cell: 2.1 nTPM
naive CD4 T-cell: 1.9 nTPM
NK-cell: 1.6 nTPM
myeloid DC: 1.5 nTPM
MAIT T-cell: 1.3 nTPM

Brain region

cerebellum: 48 nTPM
choroid plexus: 33 nTPM
hypothalamus: 29 nTPM
cerebral cortex: 28 nTPM
basal ganglia: 28 nTPM
midbrain: 28 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.91
gnomAD pLI: 0
gnomAD missense Z: 0.49
DepMap mean gene effect: 0.05
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of transcription by RNA polymerase II

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF772 as an antibody target. Whether an autoantibody or antibody against ZNF772 could matter depends on whether native ZNF772 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF772 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF772 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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