Seroatlas · Human Serome Atlas

ZNF771

Zinc finger protein 771

Also known as: DSC43, ZN771_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q7L3S4
Gene: ZNF771
Ensembl: ENSG00000179965
Chromosome: 16
Canonical length: 317 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Nucleoli

OverviewNCBI Gene

Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in nucleolus and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

317 residues, UniProt reviewed canonical sequence.

>Q7L3S4|ZNF771
     1  MPGEQQAEEE EEEEMQEEMV LLVKGEEDEG EEKYEVVKLK IPMDNKEVPG EAPAPSADPA
    61  RPHACPDCGR AFARRSTLAK HARTHTGERP FGCTECGRRF SQKSALTKHG RTHTGERPYE
   121  CPECDKRFSA ASNLRQHRRR HTGEKPYACA HCGRRFAQSS NYAQHLRVHT GEKPYACPDC
   181  GRAFGGSSCL ARHRRTHTGE RPYACADCGT RFAQSSALAK HRRVHTGEKP HRCAVCGRRF
   241  GHRSNLAEHA RTHTGERPYP CAECGRRFRL SSHFIRHRRA HMRRRLYICA GCGRDFKLPP
   301  GATAATATER CPECEGS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF771 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.42
Highest tissue expression: 23 nTPM

Expression across tissuesHPA

Tissue

cerebral cortex: 23 nTPM
amygdala: 20 nTPM
hippocampal formation: 20 nTPM
basal ganglia: 19 nTPM
cerebellum: 15 nTPM
hypothalamus: 15 nTPM

Single-cell type

breast myoepithelial cells: 34 nCPM
ovarian stromal cells: 33 nCPM
cholangiocytes: 30 nCPM
peritubular myoid cells: 28 nCPM
hepatic stellate cells: 26 nCPM
thymic myoid cells: 26 nCPM

Immune cell

naive B-cell: 3.3 nTPM
naive CD4 T-cell: 3.1 nTPM
MAIT T-cell: 2.6 nTPM
T-reg: 2.6 nTPM
memory CD4 T-cell: 2.3 nTPM
plasmacytoid DC: 2.3 nTPM

Brain region

cerebral cortex: 37 nTPM
hippocampal formation: 32 nTPM
basal ganglia: 30 nTPM
amygdala: 30 nTPM
white matter: 29 nTPM
hypothalamus: 28 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.02
gnomAD pLI: 0.06
gnomAD missense Z: 2.06
DepMap mean gene effect: -0.13
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of transcription by RNA polymerase II

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF771 as an antibody target. Whether an autoantibody or antibody against ZNF771 could matter depends on whether native ZNF771 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF771 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF771 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...