Seroatlas · Human Serome Atlas

ZNF770

Zinc finger protein 770

Also known as: FLJ20582, PRO1914, ZN770_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6IQ21
Gene: ZNF770
Ensembl: ENSG00000198146
Chromosome: 15
Canonical length: 691 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

Predicted to enable DNA binding activity and zinc ion binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

691 residues, UniProt reviewed canonical sequence.

>Q6IQ21|ZNF770
     1  MMAENNLKML KIQQCVVANK LPRNRPYVCN ICFKHFETPS KLARHYLIHT GQKPFECDVC
    61  HKTFRQLVHL ERHQLTHSLP FKCSICQRHF KNLKTFVKHQ QLHNETYQNN VKQVRRLLEA
   121  KQEKSMYGVY NTFTTEERWA LHPCSKSDPM YSMKRRKNIH ACTICGKMFP SQSKLDRHVL
   181  IHTGQRPFKC VLCTKSFRQS THLKIHQLTH SEERPFQCCF CQKGFKIQSK LLKHKQIHTR
   241  NKAFRALLLK KRRTESRPLP NKLNANQGGF ENGEIGESEE NNPLDVHSIY IVPFQCPKCE
   301  KCFESEQILN EHSCFAARSG KIPSRFKRSY NYKTIVKKIL AKLKRARSKK LDNFQSEKKV
   361  FKKSFLRNCD LISGEQSSEQ TQRTFVGSLG KHGTYKTIGN RKKKTLTLPF SWQNMGKNLK
   421  GILTTENILS IDNSVNKKDL SICGSSGEEF FNNCEVLQCG FSVPRENIRT RHKICPCDKC
   481  EKVFPSISKL KRHYLIHTGQ RPFGCNICGK SFRQSAHLKR HEQTHNEKSP YASLCQVEFG
   541  NFNNLSNHSG NNVNYNASQQ CQAPGVQKYE VSESDQMSGV KAESQDFIPG STGQPCLPNV
   601  LLESEQSNPF CSYSEHQEKN DVFLYRCSVC AKSFRSPSKL ERHYLIHAGQ KPFECSVCGK
   661  TFRQAPHWKR HQLTHFKERP QGKVVALDSV M

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF770 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.55
Highest tissue expression: 42 nTPM

Expression across tissuesHPA

Tissue

epididymis: 42 nTPM
thyroid gland: 41 nTPM
skin: 33 nTPM
liver: 27 nTPM
esophagus: 27 nTPM
placenta: 21 nTPM

Single-cell type

esophageal apical cells: 293 nCPM
esophageal suprabasal cells: 190 nCPM
suprabasal keratinocytes: 133 nCPM
neutrophil progenitors: 132 nCPM
epididymal principal cells: 123 nCPM
oocytes: 97 nCPM

Immune cell

naive CD4 T-cell: 6 nTPM
MAIT T-cell: 5.5 nTPM
memory B-cell: 4.9 nTPM
naive B-cell: 4.9 nTPM
naive CD8 T-cell: 4.9 nTPM
T-reg: 4.8 nTPM

Brain region

cerebellum: 39 nTPM
basal ganglia: 38 nTPM
cerebral cortex: 33 nTPM
thalamus: 31 nTPM
midbrain: 30 nTPM
choroid plexus: 30 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.28
gnomAD pLI: 0.99
gnomAD missense Z: 0.84
DepMap mean gene effect: 0.12
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of transcription by RNA polymerase II

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF770 as an antibody target. Whether an autoantibody or antibody against ZNF770 could matter depends on whether native ZNF770 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF770 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF770 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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