Seroatlas · Human Serome Atlas

ZNF766

Zinc finger protein 766

Also known as: ZN766_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5HY98
Gene: ZNF766
Ensembl: ENSG00000196214
Chromosome: 19
Canonical length: 468 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Centrosome

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

468 residues, UniProt reviewed canonical sequence.

>Q5HY98|ZNF766
     1  MAQLRRGHLT FRDVAIEFSQ EEWKCLDPVQ KALYRDVMLE NYRNLVSLGI CLPDLSIISM
    61  MKQRTEPWTV ENEMKVAKNP DRWEGIKDIN TGRSCAVRSK AGNKPITNQL GLTFQLPLPE
   121  LEIFQGEGKI YECNQVQKFI SHSSSVSPLQ RIYSGVKTHI FNKHRNDFVD FPLLSQEQKA
   181  HIRRKPYECN EQGKVFRVSS SLPNHQVIHT ADKPNRCHEC GKTVRDKSGL AEHWRIRTGE
   241  KPYKCKECGK LFNRIAYLAR HEKVHTGESP YKCNECGKVF SRITYLVRHQ KIHTREKPHK
   301  CNKCGKVYSS SSYLAQHWRI HTGEKLYKCN KCGKEFSGHS SLTTHLLIHT GEKPYKCKEC
   361  DKAFRHKFSL TVHQRNHNGE KPYKCHECGK VFTQVSHLAR HQKIHTGEKP YKCNECGKVF
   421  TQNSHLANHQ RIHTGEKPYK CHVCGKVFRH SSWFVQHQRS VHERVLTN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF766 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.45
Highest tissue expression: 22 nTPM

Expression across tissuesHPA

Tissue

testis: 22 nTPM
bone marrow: 15 nTPM
thymus: 13 nTPM
thyroid gland: 13 nTPM
ovary: 12 nTPM
lymph node: 12 nTPM

Single-cell type

early spermatids: 90 nCPM
late spermatids: 80 nCPM
late primary spermatocytes: 66 nCPM
undifferentiated spermatogonia: 51 nCPM
b-cells: 48 nCPM
differentiating spermatogonia: 45 nCPM

Immune cell

basophil: 52 nTPM
naive CD4 T-cell: 44 nTPM
MAIT T-cell: 36 nTPM
naive CD8 T-cell: 35 nTPM
memory B-cell: 33 nTPM
T-reg: 32 nTPM

Brain region

white matter: 23 nTPM
cerebellum: 22 nTPM
medulla oblongata: 21 nTPM
hypothalamus: 21 nTPM
pons: 20 nTPM
midbrain: 20 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ZNF766.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 67 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Hypercalcemia, infantile, 1

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.87
gnomAD pLI: 0
gnomAD missense Z: 0.11
DepMap mean gene effect: -0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of transcription by RNA polymerase II

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZNF766 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

TRIM28

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF766 as an antibody target. Whether an autoantibody or antibody against ZNF766 could matter depends on whether native ZNF766 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF766 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF766 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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