Seroatlas · Human Serome Atlas

ZNF765

Zinc finger protein 765

Also known as: ZN765_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q7L2R6
Gene: ZNF765
Ensembl: ENSG00000196417
Chromosome: 19
Canonical length: 523 aa
Protein class: Predicted intracellular proteins, Transcription factors

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

523 residues, UniProt reviewed canonical sequence.

>Q7L2R6|ZNF765
     1  MALPQGLLTF RDVAIEFSQE EWKCLDPAQR TLYRDVMLEN YRNLVSLDIS SKCMMKEFSS
    61  TAQGNREVFH AGTSQRHESH HNGDFCFQDI DKDIHDIEFQ WQEDERNGHE ALMTKIKKLT
   121  GSTERYDQNY AGNKPVKYQL GFSFHSHLPE LHIFHTEEKI DNQVVKSIHD ASLVSTAQRI
   181  SCRPETHISN DYGNNFLNSS LFTQKQEVHM REKSFQCNDS GKAYNCSSLL RKHQLIHLGE
   241  KQYKCDICGK VFNSKRYVAR HRRCHTGEKP YKCNECGKTF SQTYYLTCHR RLHTGEKPYK
   301  CEECDKAFHF KSKLQIHRRI HTGEKPYKCN ECGKTFSQKS YLTCHRRLHT GEKPYKCNEC
   361  GKTFSRKSHF TCHHRVHTGE KPYKCNECSK TFSHKSSLTY HRRLHTEEKP YKCNECGKTF
   421  NQQLTLNICR LHSGEKPYKC EECDKAYSFK SNLEIHQKIH TEENPYKCNE CGKTFSRTSS
   481  LTYHHRLHTG QKPYKCEDCD EAFSFKSNLE RHRRIYTGEK LHV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF765 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.47
Highest tissue expression: 8.3 nTPM

Expression across tissuesHPA

Tissue

parathyroid gland: 8.3 nTPM
ovary: 7.7 nTPM
placenta: 4.4 nTPM
pancreas: 4.3 nTPM
thymus: 4.1 nTPM
prostate: 4 nTPM

Single-cell type

leydig cells: 79 nCPM
adrenal cortex cells: 72 nCPM
sertoli cells: 70 nCPM
syncytiotrophoblasts: 51 nCPM
extravillous trophoblasts: 49 nCPM
peritubular myoid cells: 41 nCPM

Immune cell

eosinophil: 5.4 nTPM
MAIT T-cell: 5.1 nTPM
memory B-cell: 5 nTPM
memory CD8 T-cell: 4.4 nTPM
naive B-cell: 4 nTPM
NK-cell: 4 nTPM

Brain region

white matter: 12 nTPM
choroid plexus: 9.4 nTPM
basal ganglia: 9.1 nTPM
hypothalamus: 9 nTPM
medulla oblongata: 8.9 nTPM
pons: 8.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.96
gnomAD pLI: 0
gnomAD missense Z: -0.82
DepMap mean gene effect: 0.11
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of transcription by RNA polymerase II

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF765 as an antibody target. Whether an autoantibody or antibody against ZNF765 could matter depends on whether native ZNF765 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF765 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF765 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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