Seroatlas · Human Serome Atlas

ZNF764

Zinc finger protein 764

Also known as: MGC13138, ZN764_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96H86
Gene: ZNF764
Ensembl: ENSG00000169951
Chromosome: 16
Canonical length: 408 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Cytosol

OverviewNCBI Gene

Enables transcription coregulator activity. Involved in cellular response to glucocorticoid stimulus. Is active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

408 residues, UniProt reviewed canonical sequence.

>Q96H86|ZNF764
     1  MAPPLAPLPP RDPNGAGPEW REPGAVSFAD VAVYFCREEW GCLRPAQRAL YRDVMRETYG
    61  HLSALGIGGN KPALISWVEE EAELWGPAAQ DPEVAKCQTQ TDPADSRNKK KERQREGTGA
   121  LEKPDPVAAG SPGLKSPQAP SAGPPYGWEQ LSKAPHRGRP SLCAHPPVPR ADQRHGCYVC
   181  GKSFAWRSTL VEHVYSHTGE KPFHCTDCGK GFGHASSLSK HRAIHRGERP HRCLECGRAF
   241  TQRSALTSHL RVHTGEKPYG CADCGRRFSQ SSALYQHRRV HSGETPFPCP DCGRAFAYPS
   301  DLRRHVRTHT GEKPYPCPDC GRCFRQSSEM AAHRRTHSGE KPYPCPQCGR RFGQKSAVAK
   361  HQWVHRPGAG GHRGRVAGRL SVTLTPGHGD LDPPVGFQLY PEIFQECG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF764 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.5
Highest tissue expression: 6.5 nTPM

Expression across tissuesHPA

Tissue

stomach: 6.5 nTPM
heart muscle: 6.3 nTPM
liver: 5.7 nTPM
testis: 5.6 nTPM
ovary: 5.5 nTPM
spleen: 5 nTPM

Single-cell type

tuft cells: 23 nCPM
retinal pigment epithelial cells: 13 nCPM
early primary spermatocytes: 12 nCPM
erythrocyte progenitors: 12 nCPM
fallopian tube ciliated cells: 9.9 nCPM
granulosa cells: 9.7 nCPM

Immune cell

NK-cell: 7.2 nTPM
eosinophil: 4.4 nTPM
MAIT T-cell: 3.9 nTPM
memory CD8 T-cell: 3.7 nTPM
naive CD4 T-cell: 3.1 nTPM
memory CD4 T-cell: 3 nTPM

Brain region

cerebellum: 15 nTPM
cerebral cortex: 11 nTPM
white matter: 11 nTPM
hypothalamus: 11 nTPM
hippocampal formation: 11 nTPM
medulla oblongata: 11 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.17
gnomAD pLI: 0
gnomAD missense Z: -0.45
DepMap mean gene effect: -0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZNF764 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF764 as an antibody target. Whether an autoantibody or antibody against ZNF764 could matter depends on whether native ZNF764 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF764 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF764 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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