Seroatlas · Human Serome Atlas

ZNF763

Zinc finger protein 763

Also known as: ZN763_HUMAN, ZNF440L

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q0D2J5
Gene: ZNF763
Ensembl: ENSG00000197054
Chromosome: 19
Canonical length: 394 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

394 residues, UniProt reviewed canonical sequence.

>Q0D2J5|ZNF763
     1  MDPVACEDVA VNFTQEEWAL LDISQRKLYR EVMLETFRNL TSIGKKWKDQ NIEYEYQNPR
    61  RNFRSLIEGN VNEIKEDSHC GETFTQVPDD RLNFQEKKAS PEAKSCDNFV CGEVGIGNSS
   121  FNMNIRGDIG HKAYEYQDYA PKPYKCQQPK KAFRYHPSFR TQERNHTGEK PYACKECGKT
   181  FISHSGIRRR MVMHSGDGPY KCKFCGKAVH CLRLYLIHER THTGEKPYEC KQCVKSFSYS
   241  ATHRIHERTH TGEKPYECQQ CGKAFHSSSS FQAHKRTHTG GKPYECKQCG KSFSWCHSFQ
   301  IHERTHTGEK PCECSKCNKA FRSYRSYLRH KRSHTGEKPY QCKECRKAFT YPSSLRRHER
   361  THSAKKPYEC KQCGKALSYK FSNTPKNALW RKTL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF763 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.45
Highest tissue expression: 6.4 nTPM

Expression across tissuesHPA

Tissue

retina: 6.4 nTPM
kidney: 5.8 nTPM
ovary: 5.3 nTPM
spleen: 4.8 nTPM
thyroid gland: 4.6 nTPM
parathyroid gland: 4.5 nTPM

Single-cell type

cytotrophoblasts: 10 nCPM
late primary spermatocytes: 8.3 nCPM
paneth cells: 7.7 nCPM
distal convoluted tubule cells: 7.2 nCPM
migrating cytotrophoblasts: 6.1 nCPM
cholangiocytes: 5.3 nCPM

Immune cell

basophil: 8.5 nTPM
naive B-cell: 7.6 nTPM
neutrophil: 7.6 nTPM
eosinophil: 4.4 nTPM
non-classical monocyte: 4.1 nTPM
NK-cell: 3.9 nTPM

Brain region

white matter: 8.7 nTPM
cerebellum: 7.1 nTPM
basal ganglia: 7 nTPM
medulla oblongata: 6.8 nTPM
pons: 6.5 nTPM
cerebral cortex: 6.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.47
gnomAD pLI: 0.02
gnomAD missense Z: -0.65
DepMap mean gene effect: 0
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of transcription by RNA polymerase II

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF763 as an antibody target. Whether an autoantibody or antibody against ZNF763 could matter depends on whether native ZNF763 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF763 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF763 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...