Seroatlas · Human Serome Atlas

ZNF761

Zinc finger protein 761

Also known as: FLJ16231, FLJ35333, KIAA2033, ZN761_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q86XN6
Gene
ZNF761
Ensembl
ENSG00000160336
Chromosome
19
Canonical length
746 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

This locus represents naturally occurring readthrough transcription between the neighboring zinc finger protein 765 (ZNF765) and zinc finger protein 761 (ZNF761) genes. The readthrough transcript can encode a protein identical to the product of the ZNF761 gene. [provided by RefSeq, Apr 2017]

Canonical amino-acid sequenceUniProt

746 residues, UniProt reviewed canonical sequence.

>Q86XN6|ZNF761
     1  MAFSQGLLTF RDVAIEFSQE EWKCLDPAQR TLYRDVMLEN YRNLVSLDIS SKCTMKEFLS
    61  TAQGNREVFH AGTLQIHESH HNGDFCYQDV DKDIHDYEFQ WQEDERNGHE APMTKIKKLT
   121  GITERYDQSH ARNKPIKDQL GSSFHSHLPE MHIFQTEEKI DNQVVKSVHD ASLVSTAQRI
   181  SCRPKTHISN NHGNNFWNSS LLTQKQEVHM REKSFQCNES GKAFNYSSLL RKHQIIHLAD
   241  KYKCDVCGKL FNQKRNLACH RRCHTGENPY KCNECGKTFS QTSSLTCHRR LHTGEKPYKC
   301  EECDKAFHFK SILERHRIIH TEEKPYKCNE CGKTFRQKSI LTRHHRLHTG EKPYKCNECG
   361  KTFSHKSSLT CHHRLHTGEK PYKCNECGKT FSHKSSLTCH RRLHTGEKPY KCEECDKAYS
   421  FRSNFEIHRK IHTEDNAYKC NECGKTFSRT SSLTCHRRRH TGEQPYKCEE CDKAFRFKSN
   481  LERHRRIHTG EKPYKCNECG KTFSRKSYLT CHHRLHTGEK AYKCNECGKT FSWKSSLTCH
   541  RRLHSGEKPY KCKECGKTFN QQLTLKRHRR LHSGENPYKC EDSDKAYSFK SNLEIHQKIH
   601  TEENPYKCNE CGKTFSRTSS LTCHRRLHTG EKPYKCEECD KAFRVKSNLE GHRRIHTGEK
   661  PYKCNECGKT FSRKSYFICH HRLHTGEKPY KCNECGKNFS QKSSLICHHR LHTGEKPYKC
   721  NECGKTFSQK SNLTCHRRLH TGEKQV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF761 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.46
Highest tissue expression
69 nTPM

Expression across tissuesHPA

Tissue

  • prostate: 69 nTPM
  • placenta: 16 nTPM
  • parathyroid gland: 11 nTPM
  • skin: 10 nTPM
  • bone marrow: 9.9 nTPM
  • epididymis: 9.9 nTPM

Single-cell type

  • prostatic glandular cells: 75 nCPM
  • syncytiotrophoblasts: 69 nCPM
  • pancreatic islet cells: 47 nCPM
  • gastric progenitor cells: 35 nCPM
  • renal collecting duct intercalated cells: 29 nCPM
  • pancreatic acinar cells: 29 nCPM

Immune cell

  • NK-cell: 13 nTPM
  • T-reg: 8.4 nTPM
  • naive CD8 T-cell: 6.9 nTPM
  • memory B-cell: 6.6 nTPM
  • memory CD8 T-cell: 6.5 nTPM
  • naive CD4 T-cell: 6.5 nTPM

Brain region

  • cerebellum: 36 nTPM
  • white matter: 28 nTPM
  • hypothalamus: 24 nTPM
  • pons: 24 nTPM
  • thalamus: 24 nTPM
  • basal ganglia: 24 nTPM

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZNF761 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF761 as an antibody target. Whether an autoantibody or antibody against ZNF761 could matter depends on whether native ZNF761 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF761 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF761 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ZNF761. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...