ZNF76
Zinc finger protein 76
Also known as: D6S229E, Zfp523, ZNF523, ZNF76_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- P36508
- Gene
- ZNF76
- Ensembl
- ENSG00000065029
- Chromosome
- 6
- Canonical length
- 570 aa
- Protein class
- Predicted intracellular proteins, Transcription factors
- Subcellular location
- Nucleoplasm,Cytosol
OverviewNCBI Gene
Enables DNA-binding transcription activator activity, RNA polymerase II-specific and sequence-specific double-stranded DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
570 residues, UniProt reviewed canonical sequence.
>P36508|ZNF76
1 MESLGLHTVT LSDGTTAYVQ QAVKGEKLLE GQVIQLEDGT TAYIHQVTVQ KEALSFEDGQ
61 PVQLEDGSMA YIHRTPREGY DPSTLEAVQL EDGSTAYIHH PVAVPSESTI LAVQTEVGLE
121 DLAAEDDEGF SADAVVALEQ YASKVLHDSQ IPRNGKGQQV GDRAFRCGYK GCGRLYTTAH
181 HLKVHERAHT GDRPYRCDFP SCGKAFATGY GLKSHVRTHT GEKPYKCPEE LCSKAFKTSG
241 DLQKHVRTHT GERPFQCPFE GCGRSFTTSN IRKVHVRTHT GERPYTCPEP HCGRGFTSAT
301 NYKNHVRIHT GEKPYVCTVP GCGKRFTEYS SLYKHHVVHT HCKPYTCSTC GKTYRQTSTL
361 AMHKRSAHGE LEATEESEQA LYEQQQLEAA SAAEESPPPK RPRIAYLSEV KEERDDIPAQ
421 VAMVTEEDGA PQVALITQDG AQQVSLSPED LQALGSAISM VTQHGSTTLT IPSPDADLAT
481 SGTHTVTMVS ADGTQTQPVT IITSGAVVAE DSSVASLRHQ QVALLATANG THIAVQLEEQ
541 QTLEEAINVA TAAMQQGAVT LETTVSESGCLocalizationUniProt · AlphaFold · HPA
Whether an antibody against ZNF76 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.5
- Highest tissue expression
- 51 nTPM
Expression across tissuesHPA
Tissue
- skeletal muscle: 51 nTPM
- pituitary gland: 45 nTPM
- thyroid gland: 39 nTPM
- spleen: 33 nTPM
- adrenal gland: 33 nTPM
- ovary: 31 nTPM
Single-cell type
- epicardial cells: 421 nCPM
- cardiomyocytes: 136 nCPM
- adrenal cortex cells: 97 nCPM
- retinal amacrine cells: 87 nCPM
- myonuclei: 83 nCPM
- retinal horizontal cells: 78 nCPM
Immune cell
- gdT-cell: 17 nTPM
- MAIT T-cell: 13 nTPM
- naive CD8 T-cell: 13 nTPM
- naive CD4 T-cell: 13 nTPM
- memory CD4 T-cell: 12 nTPM
- memory CD8 T-cell: 12 nTPM
Brain region
- choroid plexus: 21 nTPM
- medulla oblongata: 17 nTPM
- thalamus: 17 nTPM
- pons: 16 nTPM
- cerebral cortex: 16 nTPM
- basal ganglia: 16 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.3
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.46
- DepMap mean gene effect
- -0.08
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- negative regulation of transcription by RNA polymerase II
- positive regulation of transcription by RNA polymerase II
- regulation of transcription by RNA polymerase II
- regulation of transcription by RNA polymerase III
Molecular functions
- DNA-binding transcription activator activity, RNA polymerase II-specific
- DNA-binding transcription factor activity, RNA polymerase II-specific
- DNA-binding transcription repressor activity, RNA polymerase II-specific
- RNA polymerase II cis-regulatory region sequence-specific DNA binding
- sequence-specific DNA binding
- sequence-specific double-stranded DNA binding
- zinc ion binding
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of ZNF76 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads ZNF76 as an antibody target. Whether an autoantibody or antibody against ZNF76 could matter depends on whether native ZNF76 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
ZNF76 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label ZNF76 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
Loading the interactive Seroatlas protein explorer...