Seroatlas · Human Serome Atlas

ZNF749

Zinc finger protein 749

Also known as: FLJ16360, ZN749_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O43361
Gene
ZNF749
Ensembl
ENSG00000186230
Chromosome
19
Canonical length
778 aa
Protein class
Predicted intracellular proteins, Transcription factors
Subcellular location
Nucleoplasm,Nuclear membrane

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

778 residues, UniProt reviewed canonical sequence.

>O43361|ZNF749
     1  MNLTEDCMVF EDVAIYFSQE EWGILNDAQR HLHSNVMLEN FALLSSVGCW HGAKDEEVPS
    61  KQCVSVRVLQ VTIPKPALST LKAQPCKMCS SILKDILHLA EHDGTHPEQG LYTCAAEHDL
   121  HQKEQIREKL TRSDEWRPSF VNHSAHVGER NFTCTQGGKD FTASSDLLQQ QVLNSGWKLY
   181  RDTQDGEAFQ GEQNDFNSSQ GGKDFCHQHG LFEHQKTHNG ERPYEFSECG ELFRYNSNLI
   241  KYQQNHAGER PYEGTEYGKT FIRKSNLVQH QKIHSEGFLS KRSDPIEHQE ILSRPTPYEC
   301  TQCGKAFLTQ AHLVGHQKTH TGEQPYECNK CGKFFMYNSK LIRHQKVHTG ERRYECSECG
   361  KLFMDSFTLG RHQRVHTGER PFECSICGKF FSHRSTLNMH QRVHAGKRLY KCSECGKAFS
   421  LKHNVVQHLK IHTGERPYEC TECEKAFVRK SHLVQHQKIH TDAFSKRSDL IQHKRIDIRP
   481  RPYTCSECGK AFLTQAHLVG HQKIHTGERP YECTQCAKAF VRKSHLVQHE KIHTDAFSKR
   541  SDLIQHKRID LRPRPYVCSE CGKAFLTQAH LDGHQKIQTG ERRYECNECG KFFLDSYKLV
   601  IHQRIHTGEK PYKCSKCGKF FRYRCTLSRH QKVHTGERPY ECSECGKFFR DSYKLIIHQR
   661  VHTGEKPYEC SNCGKFLRYR STFIKHHKVC TGEKPHECSK CRELFRTKSS LIIHQQSHTG
   721  ESPFKLRECG KDFNKCNTGQ RQKTHTGERS YECGESSKVF KYNSSLIKHQ IIHTGKRP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF749 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.49
Highest tissue expression
3.8 nTPM

Expression across tissuesHPA

Tissue

  • retina: 3.8 nTPM
  • cerebellum: 2.2 nTPM
  • skin: 2.1 nTPM
  • thymus: 1.8 nTPM
  • appendix: 1.7 nTPM
  • breast: 1.6 nTPM

Single-cell type

  • myonuclei: 49 nCPM
  • melanocytes: 26 nCPM
  • bergmann glia: 17 nCPM
  • parietal cells: 16 nCPM
  • retinal ganglion cells: 16 nCPM
  • retinal amacrine cells: 15 nCPM

Immune cell

  • naive CD4 T-cell: 1.2 nTPM
  • memory CD4 T-cell: 1.1 nTPM
  • myeloid DC: 1.1 nTPM
  • intermediate monocyte: 0.9 nTPM
  • MAIT T-cell: 0.9 nTPM
  • memory B-cell: 0.9 nTPM

Brain region

  • cerebellum: 14 nTPM
  • hippocampal formation: 9.7 nTPM
  • basal ganglia: 9.5 nTPM
  • white matter: 9.4 nTPM
  • cerebral cortex: 9.2 nTPM
  • hypothalamus: 8.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.68
gnomAD pLI
0.05
gnomAD missense Z
0.17
DepMap mean gene effect
0.08
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF749 as an antibody target. Whether an autoantibody or antibody against ZNF749 could matter depends on whether native ZNF749 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF749 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF749 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ZNF749. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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