Seroatlas · Human Serome Atlas

ZNF740

Zinc finger protein 740

Also known as: Zfp740, ZN740_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NDX6
Gene: ZNF740
Ensembl: ENSG00000139651
Chromosome: 12
Canonical length: 193 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in chromatin. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

193 residues, UniProt reviewed canonical sequence.

>Q8NDX6|ZNF740
     1  MAQASLLACE GLAGVSLVPT AASKKMMLSQ IASKQAENGE RAGSPDVLRC SSQGHRKDSD
    61  KSRSRKDDDS LSEASHSKKT VKKVVVVEQN GSFQVKIPKN FVCEHCFGAF RSSYHLKRHI
   121  LIHTGEKPFE CDICDMRFIQ KYHLERHKRV HSGEKPYQCE RCHQCFSRTD RLLRHKRMCQ
   181  GCQSKTSDGQ FSL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF740 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.51
Highest tissue expression: 11 nTPM

Expression across tissuesHPA

Tissue

thymus: 11 nTPM
spleen: 9.6 nTPM
tonsil: 8.7 nTPM
lymph node: 8.3 nTPM
cerebellum: 8.1 nTPM
small intestine: 8 nTPM

Single-cell type

adipocytes: 330 nCPM
cardiomyocytes: 81 nCPM
epicardial cells: 59 nCPM
medullary thymic epithelial cells: 24 nCPM
myonuclei: 18 nCPM
vascular smooth muscle cells: 18 nCPM

Immune cell

NK-cell: 1.4 nTPM
basophil: 1.1 nTPM
memory CD8 T-cell: 0.6 nTPM
T-reg: 0.6 nTPM
memory B-cell: 0.5 nTPM
naive B-cell: 0.5 nTPM

Brain region

cerebellum: 11 nTPM
basal ganglia: 9.3 nTPM
medulla oblongata: 9.2 nTPM
midbrain: 9.1 nTPM
thalamus: 9.1 nTPM
pons: 9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.71
gnomAD pLI: 0.19
gnomAD missense Z: 1.18
DepMap mean gene effect: -0.05
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of transcription by RNA polymerase II

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF740 as an antibody target. Whether an autoantibody or antibody against ZNF740 could matter depends on whether native ZNF740 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF740 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF740 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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